Sedative, Anticonvulsant and Analgesic activities of Fresh Leaf Essential Oil of Plectranthus aegyptiacus from Southwest Nigeria in Mice

Anxiolytic and sedative activities of the essential oil of the fresh young shoot of <i>Asparagus officinalis</i> L. in mice

“…Ketamine has been established to exhibit agonist properties on GABAA receptors (Henschel et al, 2008) hence, it suggests a possible involvement of the GABAergic pathway in the eliciting of the sedative activity of the oil (Sivam et al, 2004). Some medicinal plants act via the GABAergic system to induce their sedative/ hypnotic effect (Nogueira et al, 2000) or inhibit the effect of glutamate (an excitatory neurotransmitter) via the blockade of glutamate receptors including: N-methyl-Daspartate (NMDA), AMPA, kainate, glycine or metabotropic receptors (Trevor and Way, 2009;Akuegbe et al, 2019).…”

Behavioural activities and chemical composition of fresh leaf essential oil of Plectranthus aegyptiacus from Southwest Nigeria in mice

“…Several studies have identified diverse chemical compounds in the essential oil of Plectranthus aegyptiacus and notable ones include myrcene, limonene, camphor, borneol, terpinen-4-ol, α-terpineol, α-cubebene, β-cubebene, caryophyllene oxide, β-caryophyllene among others [7][8][9], also reported are octen-3-ol, α-terpinene, terpinene-4-ol, γ-terpinene, α-terpinyl acetate, linalool, carvacrol, β-bourbonene, β-elemene, αgurjunene, γ-elemene, aromadendrene, germacrene D, γ-muurolene and α-amorphene among others as constituents of the plant leaf [10]. Recently, we evaluated the essential oil of the fresh leaf of this species in our laboratory and results obtained showed that it demonstrated significant sedative, anticonvulsant and analgesic activities in mice [11]. However, the chemical composition of the oil used was not analysed hence, this study aimed at evaluating the oil for behavioural activities, determine its mechanism(s) of action in mice as well as characterizing its chemical constituents…”