Sedation in Screening Colonoscopy: Impact on Quality Indicators And Complications

Abstract

Sedation does not increase adenoma or polyp detection, although it leads to an increase in CIR in men and women. This effect is more pronounced in women, yet CIR of men remains higher compared with women. Quality indicators are mainly influenced by the patient's age, sex, and the endoscopists' individual performance, rather than the endoscopists' subspeciality or procedural experience.

Insertion water exchange increases right colon adenoma and hyperplastic polyp detection rates during withdrawal

“…Evidence of sedation impact on polyp [48] or adenoma detection [49] is both limited and controversial [50]. Our study provides confirmation that sedation has no influence on adenoma detection [49,51].…”

Does Propofol Sedation Increase the Cecal Intubation Rate in Colonoscopy?

“…[6] The most common causes of incomplete colonoscopy are pain, stenosis, poor bowel preparation, low BMI, advanced age, gender (female), hysterectomy story, diverticulitis, inflammatory bowel disease, loop formation of the intestines, and complication during the procedure. [3,5,7] In our series, one of the three incomplete processes had hysterectomy story, and the other had loop formation. To increase CIR, various techniques such as water infusion and carbon dioxide insufflation, and also various device modifications like pediatric, robotic, double balloon, long or very thin colonoscopy usage have been reported.…”

“…Therefore, in many countries, it is performed under either conscious or deep sedation. [10] In their very comprehensive study including more than 50,000 cases, Bannert et al [7] have shown that colonoscopy performed under sedation increased CIR in both men and women. Radaelli et al [11] reported that, CIR in colonoscopies with sedation and without sedation are in turn 84.2% and 76.1%.…”

Safety, Tolerability and Pharmacokinetics of Trimebutine 3-Thiocarbamoylbenzenesulfonate (GIC-1001) in a Randomized Phase I Integrated Design Study: Single and Multiple Ascending Doses and Effect of Food in Healthy Volunteers

“…8 Unfortunately, the increased burden on the health care system has not been associated with improvements in outcome in terms of colorectal cancer prevention. 9,10 Risks, cost, and practical inconveniences associated with the use of parenteral sedation warrant the development of orally administered, noncentrally acting colonic analgesic drugs. In this regard, an initial peripherally acting opioid agonist was evaluated for the management of visceral pain in patients undergoing full, sedation-free colonoscopy.…”