Sedation for Electroencephalography With Dexmedetomidine or Chloral Hydrate

Fernandes, Magda Lourenço; Oliveira, Welser Machado de; Santos, Maria do Carmo; Gomez, Renato Santiago

doi:10.1097/ana.0000000000000077

Cited by 13 publications

(3 citation statements)

References 26 publications

(38 reference statements)

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“…For example, it would have been convenient to compare the study groups with patients who received neither REMI nor DEX, but there were too few patients corresponding to that protocol. Another useful physiological parameter that may be impacted by choice of anesthetic agents is the power in frequency bands of the local field potential (such as effects seen in selective bands of the electroencephalogram [55], although a previous study suggested that beta power is unaffected in the MER [21]). Lastly, an important question of interest is whether patients who received DEX+REMI had similar postoperative outcomes as the group who only received REMI.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Dexmedetomidine on Microelectrode Recordings of the Subthalamic Nucleus during Deep Brain Stimulation Surgery: A Retrospective Analysis

Mathews¹,

Camalier

Kla³

et al. 2017

Stereotact Funct Neurosurg

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Background: The placement of subthalamic nucleus (STN) deep brain stimulation (DBS) electrodes can be facilitated by intraoperative microelectrode recording (MER) of the STN. Objectives: Optimal anesthetic management during surgery remains unclear because of a lack of quantitative data of the effect of anesthetics on MER. Therefore, we measured the effects of dexmedetomidine (DEX) on MER measures of the STN commonly taken intraoperatively. Methods: MER from 45 patients was retrospectively compared between patients treated with remifentanil (REMI) alone or both REMI and DEX, which are the 2 main standards of care at our center. The measures examined were population activity, such as root mean square, STN length, and number of passes yielding STN, and the single-neuron measures of firing rate and variability. Results: The addition of DEX does not affect population measures (number of passes: DEX+REMI, n = 68, REMI only, n = 154), or neuronal firing rates (number of neurons: DEX+REMI, n = 64, REMI only, n = 72), but firing rate variability was reduced. Conclusions: In this cohort, population-based measures routinely used for electrode placement in the STN were unaffected by DEX when added to REMI. Neuronal firing rates were also unaffected, but their variability was reduced, even beyond 20 min after cessation.

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Section: Discussionmentioning

confidence: 99%

The Effects of Dexmedetomidine on Microelectrode Recordings of the Subthalamic Nucleus during Deep Brain Stimulation Surgery: A Retrospective Analysis

Mathews¹,

Camalier

Kla³

et al. 2017

Stereotact Funct Neurosurg

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“…The signals were recorded by an EEG device (Nihon Kohden, Japan) using electrode positioning that adhered to 10-20 international standards (12). The EEG was monitored after using 50 mg/kg of chloral hydrate to fall children to sleep (13).…”

Section: Sleep Eeg and Qeegmentioning

confidence: 99%

Quantitative Electroencephalography in Children With Autism Spectrum Disorders

Jasim,

Hamdan,

Shareef

2024

ACTA

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The goal of this study is to compare the brain connectivity patterns of autistic patients with those of children who are developing normally and analyzing quantitative electroencephalography in children with autism. The study included 50 children who were developing normally and 60 preschoolers who met the DSM-V criteria for autism spectrum disorder. Routine and quantitative electroencephalography were carried out on each subject, as well as a Childhood Autism Rating Scale. The electroencephalograms of 76.67% of autistic children were normal; 6.67% showed focal changes, and 16.67% showed generalized changes. While the alpha power in the central and temporal areas is significantly lower in autistic children, it is unchanged in the frontal and parieto-occipital regions. Children with autism have significantly higher absolute delta and theta band activity both globally and locally. It was shown that the total and regional absolute delta and theta power activity had a significant positive correlation with the disease severity score. Quantitative electroencephalography is a more effective tool for assessing and diagnosing children with autism spectrum disorder because it shows abnormalities in all autistic children. A correlation exists between the quantitative electroencephalography data and the disease severity score.

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“…Many sedative drugs that act on the central nervous system interfere with brain waves, such as ketamine, propofol, and sevoflurane [ 2 , 3 ]. Previous studies had shown that both chloral hydrate (CH) and dexmedetomidine (DEX) were utilized for sedation during EEG, and didn't interfere with brainwaves [ 4 ].…”

Section: Introductionmentioning

confidence: 99%