Context: The increase in the use of powered two-wheelers (PTW) in large urban areas adds to the public debate on the question of legalizing the practice of filtering when traffic is congested. In recent years, filtering by PTW riders has been authorized in cities in several Australian States. In France, this practice has been authorized on an experimental basis since 1 st February 2016 on urban expressways, but for now it remains forbidden in city centers. Legalization and generalization of this practice in cities could, however, have a detrimental effect on pedestrian safety. The objective of the research presented in this paper is to estimate the risk for PTW riders of hitting and injuring a pedestrian per kilometer travelled while filtering and to compare this risk with that run while not filtering. Method: Based on the detailed study of police reports recorded on 14 sections of urban arterials roads located in the city center of Marseille (France) and a campaign of periodical observations of powered two-wheeler practices, a relative risk and its 95 % confidence interval are estimated. Results: The results show that the practice of filtering is associated with a significantly higher risk of collision with a pedestrian compared to normal driving in the traffic flow. On the sections studied, the risk is 5.30 higher (95% confidence interval [2.97; 9.43]). The main crash configurations are presented. Conclusions: In cities, filtering practices by PTW have a deleterious effect on pedestrian safety. Countermeasures concerning the road layout or enforcement seem possible to mitigate this deleterious effect. 1. Introduction Faced with transportation problems in metropolitan areas, powered two-wheelers (PTW) can provide an alternative way to travel and avoid getting stuck in congested traffic (Ducreux, 2008; Kopp, 2011). A strong increase in the use of these vehicles in congested metropolitan areas of Europe has been observed over the past twenty years (European Commission, 2013). This is largely due to their small size and good manoeuvrability, enabling their users to park their vehicle quickly, to thread through traffic and to filter when the traffic is congested, thus ensuring more regular travel times (Burge et al., 2007; Ducreux, 2008). In France, this filtering practice is still forbidden, at least in city centers. It is being tested on urban expressways in four metropolitan areas. This practice is starting to be legalized in some countries. In Belgium, since 2011, for example, motorcyclists can ride between traffic lanes going in the same direction when the vehicles in these lanes are stopped or moving slowly. This authorization applies to interurban environments as well as for urban environments 1. In Australia, most of states (New South Wales 2 , Queensland 3 , Victoria 4 , South-Australia 5 and Tasmania 6) recently authorized filtering by motorcyclists in cities and elsewhere. When traffic speed is below 30km/h,