Securing sustainable funding for viral hepatitis elimination plans

Hatzakis, Angelos; Lazarus, Jeffrey V.; Cholongitas, Εvangelos; Baptista‐Leite, Ricardo; Boucher, Charles A.; Buşoi, Cristian‐Silviu; Deuffic-Burban, S.; Chhatwal, Jagpreet; Esmat, Gamal; Hutchinson, Sharon; Malliori, Melpomeni; Matičič, Mojca; Mozalevskis, Antons; Negro, Francesco; Papandreou, George; Papatheodoridis, George V.; Peck‐Radosavljevic, Markus; Razavi, Homie; Reic, Tatjana; Schatz, Eberhard; Tözün, Nurdan; Younossi, Zobair M.; Manns, Michael P.

doi:10.1111/liv.14282

Cited by 24 publications

(29 citation statements)

References 17 publications

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“…The introduction of highly effective treatments for HCV created an unprecedented opportunity to cure almost all patients, reduce HCV transmission and eliminate the disease [21]. However, more effort is needed for screening.…”

Section: Discussionmentioning

confidence: 99%

Physician awareness of hepatitis C virus among different departments

Düzenli

Köseoğlu

2020

ceh

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Aim of the study:To determine the anti-hepatitis C virus (HCV) positivity in our region and to evaluate physician awareness of HCV among different inpatient and outpatient departments in a tertiary reference center in Turkey. Material and methods: This retrospective study was conducted between January 2017 and January 2020. The patients tested for anti-HCV for any reason were enrolled from the data of all patients admitted to our hospital, which is the reference center of the region. Results: A total of 121,492 anti-HCV assays were screened from the computerized database. Total number of patients with a positive anti-HCV result was 891 (0.81%). HCV RNA was positive in 147 (16.5%) of 891 patients and negative in 389 (43.7%) patients. Unfortunately HCV RNA was not tested in 355 (39.8%) patients. The percentages of the untested patients regarding the departments were 65.38% (n = 85/130) in medical inpatient clinics, 61.02% (n = 72/118) in surgical clinics, 16.67% (n = 88/528) medical outpatient departments, 96.8% (n = 91/94) in surgical outpatient departments, and 90.5% (n = 19/21) in the emergency department. Conclusions: The prevalence of anti-HCV positivity was found to be 0.81% and was stable in Turkey. However, the level of physician awareness for HCV was unsatisfactory, and differed between departments. Because HCV is commonly asymptomatic, positive patients should not be overlooked and adequate treatment should be administered. Awareness of physicians should be increased to prevent delays in the diagnosis of hepatitis C and to reduce the number of untreated patients.

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Section: Discussionmentioning

confidence: 99%

Physician awareness of hepatitis C virus among different departments

Düzenli

Köseoğlu

2020

ceh

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“…Furthermore, a successful antiviral treatment does not prevent reinfection of patients with risk behaviors. The WHO has recently launched a global program to achieve HCV elimination and so far, only a minority of countries have implemented measures aiming at the elimination of HCV infection as a public health threat within the next decade(s) [2]. While increasing the number of diagnosed/treated cases and reducing risky behavior in defined populations will contribute to micro-elimination of HCV, global eradication of HCV remains challenging and will likely require a protective vaccine [3,4].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Colpitts

Tsai

Zeisel

2020

IJMS

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Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.

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“…However, efforts should be deployed urgently as HBV MTCT is associated with an increased risk of liver complications 60 . As previously underlined, securing sustainable funding for viral hepatitis elimination is urgently needed 61 .…”

Section: MLmentioning

confidence: 99%

Progress towards elimination goals for viral hepatitis

Cox

El-Sayed

Kao

et al. 2020

Nat Rev Gastroenterol Hepatol

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143

159

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Is elimination of viral hepatitis by 2030 feasible? Andrea L. Cox. Hepatitis B virus (HBV) and hepatitis C virus (HCV) combined are among the top four global infectious disease killers alongside tuberculosis, malaria and HIV 1. Although the number of people in the world dying from HIV, tuberculosis and malaria have all declined since 2008, global deaths from chronic HBV and HCV infection continue to rise, with more than 1.4 million deaths each year 1. Globally, HBV-related liver disease represents the seventh highest cause of mortality worldwide 2. Given this burden, viral hepatitis elimination should be a priority. However, available evidence demonstrates that global viral hepatitis elimination by 2030 is highly unlikely. Rates of hepatitis B and C diagnosis are very low, averaging 8% and 18%, respectively, globally 1. Although some regions are approaching prophylaxis and prevalence targets for HBV infection, studies suggest that all regions must substantially scale up rates of diagnosis and access to treatment to meet the global targets 3-5. For HCV infection, 80% of high-income countries are not on track to meet HCV elimination targets by 2030, and 67% will

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Securing sustainable funding for viral hepatitis elimination plans

Abstract: The majority of people infected with chronic hepatitis C virus (HCV) in the European Union (EU) remain undiagnosed and untreated. During recent years, immigration to EU has further increased HCV prevalence.

Cited by 24 publications

References 17 publications

Physician awareness of hepatitis C virus among different departments

Physician awareness of hepatitis C virus among different departments

Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Progress towards elimination goals for viral hepatitis

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