Securin Regulates the Spatiotemporal Dynamics of Separase
Christopher G. Sorensen Turpin,
Dillon Sloan,
Marian LaForest
et al.
Abstract:Separase is a key regulator of the metaphase to anaphase transition with multiple functions. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis in mid-anaphase. The anaphase promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation. How this pathway controls the exocytic function of separase has not been investigated. During meiosis I, securin is degraded over several minutes, whil… Show more
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