Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children's health

Ketema, Rahel Mesfin; Bamai, Yu Ait; Ikeda‐Araki, Atsuko; Saito, Takeshi; Kishi, Reiko

doi:10.1016/j.ijheh.2021.113724

Cited by 9 publications

(15 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To investigate postnatal internal exposure to shorter biological half-life environmental chemicals among children, 10 phthalate metabolites [ 21 ], 13 PFR metabolites [ 19 , 20 ], and 7 bisphenols [ 18 ] were measured in 400 urine samples from 7-year-old children between 2012 and 2017, as listed in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…The most abundant metabolite was mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), followed by MnBP and mono(2-ethyl-5-hydroxyhexyl) phthalate. The least abundant was MiNP, followed by MBzP and cx-MiNP [ 21 ]. Half (7/14) of the PFR metabolites were detected in > 50% of the samples.…”

Section: Resultsmentioning

confidence: 99%

“…Secular trends in the internal exposure to phthalates, PFRs, and bisphenols were investigated from 2012 to 2017. Despite updated phthalates regulations and reducing production volumes in Japan, all of the measured phthalate metabolites showed a stable trend between 2012 and 2017 [ 21 ]. Urinary levels of BDCIPP, BCIPHIPP, and EHPHP significantly increased by 13.3%, 12.9%, and 6.7% per year, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, postnatal exposure to environmental chemicals from interior areas, diet, and consumer products may differ from those in the neonatal period as chemical production and uses change as a result of regulations and/or updated guidelines. Investigating the current internal exposure levels of shorter half-life compounds using urine samples has provided novel findings for Japanese children [ 18 , 19 , 21 ]. The internal exposure levels of certain phthalates and PFRs, which are used as plasticizers, flame retardants in polyurethane foam, and lubricants, are associated with indoor environments, such as various building types, floor materials, and ventilation habitats [ 19 , 21 , 93 ].…”

Section: Discussionmentioning

confidence: 99%

“…To assess current child exposure to environmental chemicals, urine samples of the children were collected at ages 7 and 12. These urine samples were used in the internal exposure assessment of compounds characterized by biologically short half-lives, such as phthalate, alternative plasticizers, bisphenols, phosphate flame retardants (PFRs), and insecticides [ 18 – 21 ]. Morning void urine samples were collected via uniform urinary collection kits made of polypropylene.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

Kishi

Ikeda‐Araki

Miyashita

et al. 2021

Environ Health Prev Med

Self Cite

View full text Add to dashboard Cite

Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco. Methods The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures. Results The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies. Conclusions Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future.

show abstract