Secular trends of hip fractures in Québec, Canada

Vanasse, Alain; Orzanco, Maria Gabriela; Dagenais, Pierre; Ouarda, Taha B. M. J.; Courteau, Josiane; Asghari, Shabnam; Chebana, Fateh; Martel, Barbara; Gosselin, Pierre

doi:10.1007/s00198-011-1749-0

Cited by 12 publications

(5 citation statements)

References 37 publications

(74 reference statements)

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“…Regional studies from Ontario and Quebec showed a similar trend in hip fracture rates as the national study, showing a plateau in the age-adjusted rates through the 1980s, followed by a progressive acceleration in the decline after the mid-1990s. (17)(18)(19)(20) A more recent large regional study from the province of Manitoba examined fractures in men and women aged 50 years and above between 1986 and 2006, (21) demonstrated annual declines in age-adjusted hip fracture rates of 1% in women and 0.7% in men, with an acceleration of the rate of decline after 1996 in both men and women comparable to the trend reported in the national and other regional studies.…”

Section: North Americasupporting

confidence: 55%

“…The result is expressed in percent change/year. (11) 1972-1992 R(Rochester) -0.6 þ1.4 -0.2 Melton and colleagues (2009) (12) 1980-2006 R(Rochester) -1.4 -0.06 Brauer and colleagues (2009) (13) 1985-1995 N þ0.9 þ1.6 Brauer and colleagues (2009) (13) 1995 (21) 1986-2006 R(Manitoba) -1 -0.5 Vanasse and colleagues (2012) (20) 1993 (25) 1997-2006 N -2.2 -2 Rosengren and colleagues (2013) (26) 1993-2010 N -1.2 Finland Korhonen and colleagues (2013) (27) 1970-1997 N þ2.2 þ3.8 Korhonen and colleagues (2013) (27) 1997-2010 N -1.9 -1 Iceland Siggeirsdottir and colleagues (2014) (35) 1989-2000 N þ1.3 Siggeirsdottir and colleagues (2014) (35) 2000-2008 N -2.2 Siggeirsdottir and colleagues (2014) (35) 1989-2004 N þ2.7 Siggeirsdottir and colleagues (2014) (35) 2004-2008 N 0 Norway…”

Section: North Americamentioning

confidence: 99%

“…Leslie and colleagues (2009) (16) 1985-2005 N -1.5 -1.2 -1.4 Leslie and colleagues (2011) (21) 1986-2006 R(Manitoba) -1 -0.5 Vanasse and colleagues (2012) (20) 1993 (25) 1997-2006 N -2.2 -2 Rosengren and colleagues (2013) (26) 1993-2010 N -1.2…”

Section: Canadamentioning

confidence: 99%

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Secular Trends in Hip Fractures Worldwide: Opposing Trends East Versus West

Ballane

Cauley

Luckey

et al. 2014

Journal of Bone and Mineral Research

156

117

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Despite wide variations in hip rates fractures worldwide, reasons for such differences are not clear. Furthermore, secular trends in the age-specific hip fracture rates are changing the world map of this devastating disease, with the highest rise projected to occur in developing countries. The aim of our investigation is to systematically characterize secular trends in hip fractures worldwide, examine new data for various ethnic groups in the United States, evidence for divergent temporal patterns, and investigate potential contributing factors for the observed change in their epidemiology. All studies retrieved through a complex Medline Ovid search between 1966 and 2013 were examined. For each selected study, we calculated the percent annual change in age-standardized hip fracture rates de-novo. Although occurring at different time points, trend breaks in hip fracture incidence occurred in most Western countries and Oceania. After a steep rise in age-adjusted rates in these regions, a decrease became evident sometimes between the mid-seventies and nineties, depending on the country. Conversely, the data is scarce in Asia and South America, with evidence for a continuous rise in hip fracture rates, with the exception of Hong-Kong and Taiwan that seem to follow Western trends. The etiologies of these secular patterns in both the developed and the developing countries have not been fully elucidated, but the impact of urbanization is at least one plausible explanation. Data presented here show close parallels between rising rates of urbanization and hip fractures across disparate geographic locations and cultures. Once the proportion of the urban population stabilized, hip fracture rates also stabilize or begin to decrease perhaps due to the influence of other factors such as birth cohort effects, changes in bone mineral density and BMI, osteoporosis medication use and/or lifestyle interventions such as smoking cessation, improvement in nutritional status and fall prevention.

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Section: North Americasupporting

confidence: 55%

Section: North Americamentioning

confidence: 99%

See 1 more Smart Citation

Secular Trends in Hip Fractures Worldwide: Opposing Trends East Versus West

Ballane

Cauley

Luckey

et al. 2014

Journal of Bone and Mineral Research

156

117

View full text Add to dashboard Cite

show abstract

“…But hip fracture incidence varies among countries [4,5]. During the past decade, hip fracture incidence has declined in most Western countries and Oceania [5][6][7][8][9][10][11][12][13][14], reached a plateau [15,16] and increased in some countries in Asia and South America [5,17]. In France, we previously showed that the incidence of hip fractures decreased in both genders from 2002 to 2008 [18].…”

Section: Introductionmentioning

confidence: 99%

Changes in number and incidence of hip fractures over 12 years in France

Briot

Maravic

Roux

2015

Bone

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“…In this respect, healthy elderly individuals are particularly prone to catastrophic events at any moment of their lives. One stressful event for individuals aged 65 and older is a fall that results in a fracture of the hip (HF) [3,4]. HF can have serious outcomes such as chronic pain, disability, high morbidity, susceptibility to major depression, loss of autonomy in individuals who were generally autonomous before the event and, frequently, institutionalization.…”

Section: Introductionmentioning

confidence: 99%

Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study

Baëhl

Garneau²,

Lorrain³

et al. 2016

Gerontology

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Background: Healthy elderly individuals are particularly prone to catastrophic events at any moment of their lives. One stressful event for individuals aged 65 and older is a fall that results in a fracture of the hip (HF). HF causes a state of inflammation that may affect immune responses. In this connection, we have reported that HF induced alterations in neutrophil functions. Objective: To assess the impact of HF on classical (cM), intermediate (iM) and non-classical (ncM) monocyte subsets. Methods: Distribution, functions (chemotaxis, phagocytosis, superoxide production and cytokine production), phenotype and activation (NF-κB and PI3K) were evaluated in monocyte subsets before surgery and 6 weeks and 6 months after the event. Results: The distribution of cM and ncM was unchanged, but iM transiently increased before surgery. Sustained increases (iM response to CCL2 and CX3CL1) and decreases (cM and ncM response to CCL2) in chemotaxis were observed. Phagocytosis and superoxide production were impaired in cM but not in iM or ncM. Sustained expression of HLA-DR occurred in cM but not in iM and ncM. Sustained decreased expression of CD11b occurred only in ncM. Sustained decreases (cM and ncM) and increases (iM) in CCR2 expression were observed. An elevated expression of CX3CR1 was found only in iM. cM produced elevated quantities of TNFα. There was a transient oxidative burst of production before surgery in iM and a sustained decrease in ncM. IL-10 production was severely impaired in cM and decreased in iM prior to surgery. Sustained activation (cM), inhibition (ncM) and transient activation (iM) of NF-κB were observed. Activation of PI3K was severely impaired in cM and ncM but was sustained in iM. Conclusion: HF had more impact on cM and ncM functions than on iM. HF triggered a switch in cM functions from phagocytic to inflammatory elevated TNFα-producing cells. These changes may impact clinical outcomes of HF with respect to inflammation, opportunistic infections and physical recovery.

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Secular trends of hip fractures in Québec, Canada

Abstract: Differences observed in hip fracture rates as well as in secular trends between age groups and gender emphasise the need for decision makers to rely on results based on age-specific and sex-specific analyses.

Cited by 12 publications

References 37 publications

Secular Trends in Hip Fractures Worldwide: Opposing Trends East Versus West

Secular Trends in Hip Fractures Worldwide: Opposing Trends East Versus West

Changes in number and incidence of hip fractures over 12 years in France

Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study

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