Secular trends in nosocomial primary bloodstream infections in the United States, 1980–1989

Banerjee, Shailen N.; Emori, T. Grace; Culver, David H.; Gaynes, Robert P.; Jarvis, William R.; Horan, Teresa C.; Edwards, Jonathan R.; Tolson, James S.; Henderson, Tonya S.; Martone, William J.

doi:10.1016/0002-9343(91)90349-3

Cited by 777 publications

(375 citation statements)

References 11 publications

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“…Blood cultures revealed C. albicans in the 5 patients who were diagnosed with ocular candidiasis on initial examination while the 3 patients who turned positive after initial negative examination cultured C. albicans (1), Torulopsis glabrata (1) and C. parapsilosis (1). The number of patients who turned positive after an initial negative examination is too small to make any conclusions as to whether the infecting organism has a role in the time to development of ocular infection.…”

Section: Resultsmentioning

confidence: 98%

Should all patients with candidaemia have an ophthalmic examination to rule out ocular candidiasis?

Krishna

Amuh

Lowder

et al. 2000

Eye

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Section: Resultsmentioning

confidence: 98%

Should all patients with candidaemia have an ophthalmic examination to rule out ocular candidiasis?

Krishna

Amuh

Lowder

et al. 2000

Eye

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“…1 However, in someoften immunocompromised-hosts, it has the capacity to colonize various tissues and organs, causing a range of diseases. It is the fungal species most frequently isolated in hospital-acquired infections 2 and incidences of infection have risen with the increased prevalence of immunosuppressive therapies and broad-spectrum antibiotic use. 3 C. albicans is a member of the genus Candida, and is the most frequent causative agent of candidiasis in humans.…”

Section: Candida Albicans Infections In Humansmentioning

confidence: 99%

Genetic analysis of innate immunity in resistance to Candida albicans

2004

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Systemic candidiasis is a significant cause of nosocomial infections and the mechanisms of defense against Candida albicans in humans remain poorly understood. Studies in animal models have demonstrated the importance of innate immunity in controlling the response to infection. Although Th1 cytokines have been shown to direct the overall outcome of infection, the precise role of the Th1/Th2 response and, more generally, the adaptive immune response as a whole, in systemic candidiasis, appears to apply mainly to the development of resistance to reinfection. A genetic approach to the identification of host factors regulating pathogenesis and susceptibility to C. albicans infection has been used in humans and in mouse models of infection. Mouse mutants bearing experimentally induced mutations in specific genes have provided a systematic tool for directly assessing the role of individual proteins in C. albicans susceptibility. Inbred mouse strains have been valuable in showcasing the spectrum of naturally occurring variations in initial susceptibility to infection, and type of disease developed. Crosses between resistant and susceptible strains have led to the detection of additional gene effects affecting innate immunity. Of particular interest is the major effect of a naturally occurring loss-of-function mutation in the C5 complement component that has become fixed in many inbred strains. These and other studies have shown that both a functional complement pathway and robust inflammatory response are critical for resistance to C. albicans.

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“…Nos casos de sepse, foram recuperadas 29 amostras de sepse primária, em que os cocos Gram-positivos predominaram (58,7%) e, 21 de sepse secundária onde os bacilos Gram-negativos foram os agentes mais frequentes (71,4%). Os microrganismos mais importantes recuperados foram Staphylococcus coagulase-negativa (SCN) representando 30% e, Pseudomonas aeruginosa (8%), dados similares de estudos recentes 10,11 . Comparando com outros patógenos importantes, a presença de Candida sp (6%) foi compatível com estudos americanos 6 , por outro lado a presença de Enterococcus sp foi incomum (3,7%).…”

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Sepse, sepse grave e choque séptico: aspectos clínicos, epidemiológicos e prognóstico em pacientes de Unidade de Terapia Intensiva de um Hospital Universitário

Carvalho

Vieira

Filho

et al. 2010

Rev. Soc. Bras. Med. Trop.

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INTRODUÇÃO: Sepse é considerada doença grave com alta mortalidade. O objetivo desse estudo foi determinar a incidência e evolução da sepse em pacientes críticos. MÉTODOS: Foi realizada vigilância prospectiva de sepse na Unidade de Terapia Intensiva de Adultos, de abril-dezembro de 2007. RESULTADOS: A frequência de pacientes/dia foi 442. Setenta e cinco (18,6%) pacientes tinham sepse; destes, 72% hospitalar. As taxas de sepse grave e choque séptico por paciente/dia foram 5,0 e 3,1, respectivamente. A mortalidade total foi 34,6%. Sessenta e um por cento dos casos tinham diagnóstico microbiológico. CONCLUSÕES: A sepse apresentou-se numa frequência maior, do que a usualmente descrita na literatura.

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Secular trends in nosocomial primary bloodstream infections in the United States, 1980–1989

Cited by 777 publications

References 11 publications

Should all patients with candidaemia have an ophthalmic examination to rule out ocular candidiasis?

Should all patients with candidaemia have an ophthalmic examination to rule out ocular candidiasis?

Genetic analysis of innate immunity in resistance to Candida albicans

Sepse, sepse grave e choque séptico: aspectos clínicos, epidemiológicos e prognóstico em pacientes de Unidade de Terapia Intensiva de um Hospital Universitário

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