Secukinumab in the Treatment of Generalized Pustular Psoriasis: A Case report

Polesie, Sam; Lidholm, Anette Gente

doi:10.2340/00015555-2467

Cited by 19 publications

(26 citation statements)

References 2 publications

(2 reference statements)

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“…Its efficacy and safety for GPP patients have been reported in a recent open‐label trial . Several case studies of GPP successfully treated with secukinumab have also been reported . In 2016, another anti‐IL‐17 antibody, ixekizumab, and an anti‐IL‐17 receptor antibody, brodalumab, were approved for health insurance coverage in Japan for patients with psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma.…”

Section: Chapter V: Strength Of Recommendations and Comments For Eachmentioning

confidence: 99%

“…142 Several case studies of GPP successfully treated with secukinumab have also been reported. [143][144][145] In 2016, another anti-IL-17 antibody, ixekizumab, and an anti-IL-17 receptor antibody, brodalumab, were approved for health insurance coverage in Japan for patients with psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. The efficacy and safety of ixekizumab and brodalumab including GPP patients in an open-label trial have been reported.…”

Section: Cq16 Are Biologics Other Than Tnf-a Inhibitors Effective Fomentioning

confidence: 99%

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Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

190

456

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Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan. Its contents include the diagnostic and severity classification criteria for GPP, its pathogenesis, and recommendations for the treatment of GPP. Since there are few clinical trial data with high levels of evidence for this rare disease, recommendations by the committee are described in the present guidelines.

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Section: Chapter V: Strength Of Recommendations and Comments For Eachmentioning

confidence: 99%

Section: Cq16 Are Biologics Other Than Tnf-a Inhibitors Effective Fomentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

190

456

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“…Some success was found with the use of anakinra, an IL‐1Ra . Good efficacy has been reported with the use of secukinumab and ixekizumab, which are anti‐IL‐17A monoclonal antibodies . A promising new treatment option with a rapid onset of action is brodalumab, an anti‐IL‐17‐receptor A monoclonal antibody .…”

Section: Treatmentmentioning

confidence: 99%

“…70,71 Good efficacy has been reported with the use of secukinumab and ixekizumab, which are anti-IL-17A monoclonal antibodies. [72][73][74][75][76][77] A promising new treatment option with a rapid onset of action is brodalumab, an anti-IL-17-receptor A monoclonal antibody. 78 More recently, granulocyte and monocyte apheresis (GMA) has been employed in cases recalcitrant to other medications, or in special populations, such as very young or old patients, pregnant and those infected with hepatitis.…”

Section: Adult Gppmentioning

confidence: 99%

Generalized pustular psoriasis: a review and update on treatment

Hoegler

John

Handler

et al. 2018

Acad Dermatol Venereol

148

193

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Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau. Treatment is not well established, but includes the use of retinoids, methotrexate, cyclosporine, corticosteroids, TNF-alpha inhibitors, topical therapy and phototherapy. The use of TNF-alpha inhibitors may result in the formation of antidrug antibodies and should be administered with methotrexate.

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“…It is produced by T cells as well as other immune cells and leads to proliferation and activation of keratinocytes, which then attract and stimulate the infi ltrating immune cells such as neutrophils [ 26,27 ] Interleukin-17A antibodies such as secukinumab and ixekizumab have been used successfully in the treatment of psoriasis vulgaris [ 28 ] and generalized pustular psoriasis [ 29,30 ] . It is produced by T cells as well as other immune cells and leads to proliferation and activation of keratinocytes, which then attract and stimulate the infi ltrating immune cells such as neutrophils [ 26,27 ] Interleukin-17A antibodies such as secukinumab and ixekizumab have been used successfully in the treatment of psoriasis vulgaris [ 28 ] and generalized pustular psoriasis [ 29,30 ] .…”

mentioning

confidence: 99%