“…3) ; References in Figure 3: Webb et al, 1999[ 149 ]; Klinge, 2000[ 69 ]; Begam et al, 2017[ 21 ]; El Mohtadi, 2019[ 41 ]) that is typical of the NR family, consisting of six domains ( A-F ) (Kuiper et al, 1998[ 72 ]; Klinge, 2000[ 69 ]; Begam et al, 2017[ 21 ]). ER proteins are expressed in skin, suggesting estrogen regulates skin function, maintenance and/or turnover (Ashworth, 2005[ 14 ]). While ER-α and ER-β have 97 % homology in the C domain that acts as a DNA-binding domain (DBD), they only have 55 % homology in the E domain which forms the ligand-binding domain (LBD) (Barkhem et al, 1998[ 18 ]; Webb et al, 1999[ 149 ]; Klinge, 2000[ 69 ]), enabling targeted ER activation using artificial ligands with ER-specific binding affinity.…”