Abstract. We explicitly construct genus-2 Lefschetz fibrations whose total spaces are minimal symplectic 4-manifolds homeomorphic to complex rational surfaces CP 2 #p CP 2 for p = 7, 8, 9, and to 3CP 2 #q CP 2 for q = 12, . . . , 19. Complementarily, we prove that there are no minimal genus-2 Lefschetz fibrations whose total spaces are homeomorphic to any other simply-connected 4-manifold with b + ≤ 3, with one possible exception when b + = 3. Meanwhile, we produce positive Dehn twist factorizations for several new genus-2 Lefschetz fibrations with small number of critical points, including the smallest possible example, which follow from a reverse engineering procedure we introduce for this setting. We also derive exotic minimal symplectic 4-manifolds in the homeomorphism classes of CP 2 #4CP 2 and 3CP 2 #6CP 2 from small Lefschetz fibrations over surfaces of higher genera.