Abstract:Their position at the crypt base puts Paneth cells in a unique position to interact with active intestinal stem cells and influence the intestinal stem cell niche. However, they also interact with other cells and organ systems and possess the ability to take on stem cell-like characteristics under certain circumstances. Paneth cells are professional secretory cells that classically play a role in the innate immune system by secreting antimicrobial factors into the lumen to control enteric bacteria. In this rol… Show more
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