Secretory Potentials and Secretion in the Sublingual Gland of the Cat

Lundberg, A.

doi:10.1038/1771080a0

Cited by 22 publications

(5 citation statements)

References 2 publications

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“…Many responses of the TB-2 (putative dark) cells resembled the hyperpolar-izing secretory potentials recorded from cat sublingual gland (Lundberg, 1956). This suggests that TB-2 cells may have a secretory function, as proposed by Farbman and Yonkers (1971) and Murray (1971) for dark cells.…”

Section: Taste Bud Cell Structure and Functionsupporting

confidence: 69%

Intracellular characteristics and responses of taste bud and lingual cells of the mudpuppy.

West¹,

Bernard²

1978

The Journal of General Physiology

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A B S TRACT Intracellular recordings of membrane potentials of mudpuppy lingual cells were made with micropipette electrodes. Three types of cells were distinguished by their responses to chemical stimulation. Surface epithelial (SE) cells outside of taste buds responded with large membrane potential and resistance changes to a variety of stimuli representing the four taste qualities. Salts and acids evoked particularly large potential changes, and MgCI~, acids, and quinine greatly increased the membrane resistance. One type of taste bud cell (TB-1) was characterized by large depolarizations to K salts, and the other type of taste bud cell (TB-2) characteristically hyperpolarized to MgCI2, acid, and sugar solutions. Membrane resistance changes accompanying TB-1 and TB-2 cell responses were relatively small compared to those of SE cells. Electrotonic coupling was observed between pairs of SE and TB-2 cells but not for pairs of TB-I cells nor cells of different types. After recording cell responses, dye-marking allowed verification of results in situ and histologically. From the identification of cells in section, it is hypothesized the TB-1 and TB-2 cells correspond to light and dark cells, respectively. Responses of TB-1 cells imply a taste receptive function; whereas TB 2-cell responses suggest secretory, supportive, and (or) receptive functions. Factors affecting cellular characteristics, non-taste bud cell responsiveness, response mechanisms, and function of electrotonic coupling are discussed in relation to taste reception.

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Section: Taste Bud Cell Structure and Functionsupporting

confidence: 69%

Intracellular characteristics and responses of taste bud and lingual cells of the mudpuppy.

West¹,

Bernard²

1978

The Journal of General Physiology

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“…have already reported that 10-8 A passed through the recording barrel of a micropipette failed to effect the response. If the response is intracellular, then either the membrane potential was not changed sufficiently by the current because of the cell's low total resistance, or the generator of these potentials 498 RESPONSES OF FISH RETINA is an active ionic movement independent of membrane potential, somewhat analogous to what Lundberg (1956) reported of salivary-gland cells. If the recorded response is extracellular the explanation is simplified, because the current would then produce little change across the active membrane.…”

Section: P Gouras Methodsmentioning

confidence: 85%

Graded potentials of bream retina

Gouras¹

1960

The Journal of Physiology

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“…1). It has been shown previously that NO3 is a bad substitute for C1 in glandular secretion (Lundberg, 1956;Seldin & Hoshiko, 1966;Petersen, 1988). This is probably due to the fact that the active transport (secretion) of anions requires an active cotransport system (Silva et al, 1977), and NO~ cannot substitute for CI-in the cotransport system (Kinne, 1988).…”

Section: Discussionmentioning

confidence: 94%

Prostaglandin E2 enhances the sodium conductance of exocrine glands in isolated frog skin (Rana esculenta)

Nielsen

1990

J. Membrain Biol.

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Prostaglandins are known to stimulate the active transepithelial Na+ uptake and the active secretion of Cl- from the glands of isolated frog skin. In the present work the effect of prostaglandin E2 (PGE2) on the glandular Na+ conductance was examined. In order to avoid interference from the Na+ uptake and the glandular Cl- secretion the experiments were carried out on skins where the Cl- secretion was inhibited (the skins were bathed in Cl- Ringer's solution in the presence of furosemide, or in NO3- Ringer's solution), and the active Na+ uptake was blocked by the addition of amiloride. Transepithelial current, water flow and ion fluxes were measured. A negative current was passed across the skins (the skins were clamped at -100 mV, basolateral solution was taken as reference). When PGE2 was added to the skins under these experimental conditions, the current became more negative; this was mainly due to an increase in the Na+ efflux. Together with the increase in Na+ efflux a significant increase of the water secretion was observed. The water secretion was coupled to the efflux of Na+, and when one Na+ was pulled from the basolateral to the apical solution via this pathway 230 molecules of water followed. From the data presented it is suggested that this pathway for Na+ is confined to the exocrine glands.

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Secretory Potentials and Secretion in the Sublingual Gland of the Cat

Cited by 22 publications

References 2 publications

Intracellular characteristics and responses of taste bud and lingual cells of the mudpuppy.

Intracellular characteristics and responses of taste bud and lingual cells of the mudpuppy.

Graded potentials of bream retina

Prostaglandin E2 enhances the sodium conductance of exocrine glands in isolated frog skin (Rana esculenta)

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