Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: Effects of alpha-adrenergic blockade

Ring, Christopher; Harrison, Lesley K.; Winzer, Alexandra; Drayson, Mark T.; Kendall, M. J.

doi:10.1017/s0048577200991030

Cited by 24 publications

(30 citation statements)

References 6 publications

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“…This suggest that power was not a limiting factor in detecting gender differences in earlier studies~Herbert KiecoltGlaser et al, 1984;Mills et al, 1995;Ring et al, 2000;Winzer et al, 1999!. Nevertheless, women had more circulating neutrophils and CD4ϩ T cells but fewer NK cells than men both at rest and during the tasks.…”

Section: Gender Differencesmentioning

confidence: 81%

“…Salivary sIgA has been found to increase in response to active laboratory stress tasks, such as mental arithmetic~Bosch et al, 2001;Carroll et al, 1996;Ring et al, 1999Ring et al, , 2000Willemsen et al, 1998;Willemsen, Ring, McKeever, & Carroll, 2000;Winzer et al, 1999!. Somewhat more mixed results have been found for passive stress.…”

mentioning

confidence: 99%

“…The few studies that have explored gender differences in immune reaction to acute stress report that men and women do not differ in either cellular reactions Herbert et al, 1994;Kiecolt-Glaser et al, 1984;Mills et al, 1995! or sIgA reactions~Kiecolt-Glaser et al, 1984Ring et al, 2000;Winzer et al, 1999!. However, it is possible that these null findings reflect low power; studies have either suffered from small sample sizes~Herbert et al, 1994;Winzer et al, 1999;Ring et al, 2000!…”

mentioning

confidence: 99%

“…or sIgA reactions~Kiecolt-Glaser et al, 1984Ring et al, 2000;Winzer et al, 1999!. However, it is possible that these null findings reflect low power; studies have either suffered from small sample sizes~Herbert et al, 1994;Winzer et al, 1999;Ring et al, 2000! or a preponderance of one gender~Mills et al, 1995KiecoltGlaser et al, 1984!.…”

mentioning

confidence: 99%

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Cellular and mucosal immune reactions to mental and cold stress: Associations with gender and cardiovascular reactivity

Willemsen¹,

Ring²,

Drayson³

2002

Psychophysiol.

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To examine gender differences in immune reactions to stress and relationships between immune and cardiovascular reactivity, measures of cellular and mucosal immunity and cardiovascular activity were recorded in 77 men and 78 women at rest and in response to active~mental arithmetic! and passive~cold pressor! stress tasks. Both tasks reduced CD4ϩ T cells and the CD408 ratio. Total lymphocytes, NK cells, CD8ϩ T cells, and secretory immunoglobulin Ã sIgA! increased with active stress. Passive stress decreased sIgA. At rest, men had more NK cells, less CD4ϩ T cells, and fewer neutrophils than women. Mental stress increased sIgA in men but not women. Cardiovascular reactivity to active stress was associated with increases in NK cells. The data support the hypothesis that stress-related increases in lymphocytes are beta-adrenergically mediated, and suggest that the fall in CD4ϩ T cells may be alpha-adrenergically driven. Mechanisms underlying sIgA reactions are more difficult to determine. Men and women differed in some cell counts, but not in reactivity, although gender influenced sIgA reactions to arithmetic.

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Section: Gender Differencesmentioning

confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cellular and mucosal immune reactions to mental and cold stress: Associations with gender and cardiovascular reactivity

Willemsen¹,

Ring²,

Drayson³

2002

Psychophysiol.

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“…Nevertheless, since hormone levels in saliva are known to reflect well the levels in plasma, measurement of salivary stress hormones offers the prospect of a very convenient and useful approach for research into stress. Examples of possible salivary secreted hormones are immunoglobulin-A (sIgA) [10,11], salivary amylase [12], and salivary Chromogranin-A (CgA) [13]. Salivary CgA was recently reported to be a useful biochemical marker of stress.…”

Section: Introductionmentioning

confidence: 99%

Relationship between salivary Chromogranin-A and stress induced by simulated monotonous driving

Yamakoshi

Park

Jang

et al. 2009

Med Biol Eng Comput

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Abstract:The purpose of the present study was to evaluate the use of salivary Chromogranin-A (CgA), which is already used in general as a mental stress marker, for studying the stressful situation created by simulated monotonous driving. After informed consent 25 healthy male & female subjects were studied, under constant environment-controlled conditions. We measured the following physiological variables: blood pressure (BP), cardiac output (CO), total peripheral resistance (TPR), normalized pulse volume (NPV) as an index of alpha-adrenergic sympathetic activity to the finger arteriolar vessels, levels of cortisol and CgA during monotonous driving. The induced stress led to the expected decreases in NPV and increases in TPR and BP caused by peripherally-related sympathetic acceleration. However, CgA levels were found to fall gradually in accordance with the gradual increase of subjective rating of stress (SRS) and significantly (p<0.01) decreased over the period of the simulated monotonous driving.Our hypothesis for the gradual decrease of CgA levels during the simulated monotonous driving is as follows. CgA, catestatin and Catecholamines are co-released into the extra-cellular environment. Peripheral sympathetic activity was accelerated by stress resulting from the simulated monotonous driving. Upon peripheral vessel constriction, an increase in total peripheral resistance (TPR) then increased BP which, in turn, activated catestatin. Consequently, secretion of CgA was blocked by the co-secreted catestatin from chromaffin granules. The results obtained strongly indicate that, although CgA has been reported as a possible marker of stress, CgA levels are not increased in the stressful situation of simulated monotonous driving.

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Use of saliva for assessment of stress and its effect on the immune system prior to gross anatomy practical examinations

Lester

Brown

Aycock

et al. 2010

Anatomical Sciences Ed

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The objective of this study was to determine the longitudinal effects of a series of stressful gross anatomy tests on the immune system. Thirty-six freshman occupational therapy students completed a written stress evaluation survey, and saliva samples were obtained at baseline and prior to each of three timed-practical gross anatomy tests. Cortisol, secretory IgA (sIgA), and IL-12 concentrations were measured within the salivary samples by enzyme-linked immunosorbent assay. The total scores from the stress surveys were used as markers for environmental stress. Data were compiled for each student at baseline and prior to each examination and were compared by repeated-measures MANOVA and Pearson's correlation test. Following normalization for protein concentration and flow rate, the concentrations of IL-2, IL-6, IL-12, and sIgA progressively increased from baseline to the third test. Cortisol concentrations, following normalization for flow rate, were highest prior to the first test and became significantly reduced prior to second and third test. Prior to second and third test, salivary concentrations of IL-6, IL-2, IL-12, and sIgA were significantly correlated (P < 0.05). In contrast, prior to third test, there was a negative correlation between salivary concentrations of cortisol and IL-12 (P < 0.05). Progressive increases in salivary sIgA, IL-6, IL-2, and IL-12 concentrations from the first to the third test coincident to decreased salivary cortisol suggest that the initial examination stressors precede significant effects on the immune system. These data suggest that there may be latent effects of examination stress on the immune system and that saliva can be used to predict these effects.

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Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: Effects of alpha-adrenergic blockade

Cited by 24 publications

References 6 publications

Cellular and mucosal immune reactions to mental and cold stress: Associations with gender and cardiovascular reactivity

Cellular and mucosal immune reactions to mental and cold stress: Associations with gender and cardiovascular reactivity

Relationship between salivary Chromogranin-A and stress induced by simulated monotonous driving

Use of saliva for assessment of stress and its effect on the immune system prior to gross anatomy practical examinations

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