Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis

Abstract

SUMMARYSecretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specifie for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN). 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membranous nephropathy (MGN) and 40 healthy controls. Secretory IgA levels were elevated in both saliva and serum of patients with primary glomerulonephrilis (/'<0-05; Mann-Whitney test) regardless of the histological type ofthe primary glomerulonephritis. Salivary IgA 1 and IgA2 levels were inereased in the saliva of patients with IgAGN. INS and MGN {P< 005; Mann-Whitney test)-The monomeric/total IgA ratio, and interferon-gamma and soluble IL-2 receptor levels, in saliva did not differ between the patients and controls (P>005; MannWhitney test). We conclude that the mucosal immune systetn is activated in forms ofglomerulonephritis other than IgAGN.

Increased risk of end-stage renal disease in individuals with coeliac disease

“…Individuals with primary glomerulonephritis often display an activated mucosal immune system,11 increased gut permeability12 13 and an increased number of mucosal intraepithelial T lymphocytes,12 suggesting impaired oral tolerance in the pathophysiology of glomerulonephritides 14. Several studies have demonstrated increased levels of CD autoantibodies in individuals with renal disease 15 16.…”

The level of urinary secretory immunoglobulin A (sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes

“…Next to its presence in mucosal secretions, small amounts of sIgA can also be found in human serum. It has been suggested that sIgA might play a pathogenic role in IgAN; substantial evidence has demonstrated that serum sIgA was elevated in patients with IgAN [5][6][7][8][9][10] and, recently, studies including ours revealed successfully the deposition of sIgA in glomeruli of some patients with IgAN [11][12][13]. However, only one study of 31 patients with chronic glomerulonephritis, including 10 patients with IgAN, found that the level of urinary sIgA was significantly higher than normal controls [14].…”

Secretory IgA Induces Tolerogenic Dendritic Cells through SIGNR1 Dampening Autoimmunity in Mice

“…In mice, orally delivered SIgA induces mucosal and systemic responses associated with IL-10 and TGF-b expression in draining mesenteric (16). Although SIgAs are found in the human bloodstream of healthy individuals (17)(18)(19) and are increased in serum from patients with IgA-associated diseases (19)(20)(21)(22)(23), their systemic role in immunity remains unknown.…”