Secretory function of the rabbit common bile duct

Chenderovitch, J

doi:10.1152/ajplegacy.1972.223.3.695

Cited by 37 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of measurement of electrolyte excretion in dog bile, Wheeler et al (156) identified two distinct anatomic secretory sites, one responsible for bile acid-dependent bile flow and one (more distal) important for the choleretic effect of secretin. In support of the secretory capacity of the ductal epithelium, studies in dogs and rabbits have shown secretion of water and electrolytes by an isolated segment of the extrahepatic bile duct in situ (103,131) and in vitro (40). Studies in dogs with bile fistula (155) and isolated, perfused pig liver (66) have shown that secre-tin increases bicarbonate-rich bile secretion and that the increase in bile flow is proportional to the logarithm of the dose of secretin.…”

Section: Historical Backgroundmentioning

confidence: 99%

Regulation of cholangiocyte bicarbonate secretion

Kanno

LeSage²,

Glaser³

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

140

168

View full text Add to dashboard Cite

The objective of this review article is to discuss the role of secretin and its receptor in the regulation of the secretory activity of intrahepatic bile duct epithelial cells (i.e., cholangiocytes). After a brief overview of cholangiocyte functions, we provide an historical background for the role of secretin and its receptor in the regulation of ductal secretion. We review the newly developed experimental in vivo and in vitro tools, which lead to understanding of the mechanisms of secretin regulation of cholangiocyte functions. After a description of the intracellular mechanisms by which secretin stimulates ductal secretion, we discuss the heterogeneous responses of different-sized intrahepatic bile ducts to gastrointestinal hormones. Furthermore, we outline the role of a number of cooperative factors (e.g., nerves, alkaline phosphatase, gastrointestinal hormones, neuropeptides, and bile acids) in the regulation of secretin-stimulated ductal secretion. Finally, we discuss other factors that may also play an important role in the regulation of secretin-stimulated ductal secretion.

show abstract

Section: Historical Backgroundmentioning

confidence: 99%

Regulation of cholangiocyte bicarbonate secretion

Kanno

LeSage²,

Glaser³

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

140

168

View full text Add to dashboard Cite

show abstract

“…14,18 Bile duct secretion is associated with a net flux of Cl Ϫ and HCO 3 Ϫ into the lumen and generation of a lumen negative potential, consistent with a role for electrogenic Cl Ϫ transport. 19,20 Additionally, a small conductance K + channel has been identified in cholangiocytes and may play a role in maintaining a membrane potential difference necessary for transepithelial secretion. 21 The findings that (a) CFTR is localized to the apical membrane of cholangiocytes and (b) secretin-activated Cl Ϫ channels have properties analogous to CFTR support a working model that postulates an important role for CFTR Cl Ϫ channels in the regulation of ductular secretion.…”

Section: Cftr Contributes To Ductular Bile Formationmentioning

confidence: 99%

Cholangiocyte Biology and Cystic Fibrosis Liver Disease

Feranchak¹,

Sokol²

2001

Semin Liver Dis

117

View full text Add to dashboard Cite

Cystic fibrosis (CF) is one of the most common inherited diseases in the white population. The disease results from mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). How this gene defect leads to the clinical manifestations of the disease, however, is not entirely clear. CFTR functions as a Cl(-) channel in the apical membrane of most secretory epithelia, including biliary epithelial cells, or cholangiocytes. In cholangiocytes, CFTR appears to be an important determinant of biliary secretion and bile flow. Additionally, recent evidence suggests that CFTR regulates other membrane transporters, channels, and proteins. Improving life expectancy has led to an increasing recognition of hepatobiliary complications from CF. The true prevalence of CF liver disease is unknown, but may affect up to 17-25% of CF patients. Clinical manifestations include hepatic steatosis, neonatal cholestasis, focal nodular cirrhosis, multilobular cirrhosis, and biliary tract complications. Why only a subset of CF patients develops severe liver disease and others with the same genotype do not is one of the many scientific curiosities of this disease. This review focuses on the function of CFTR in cholangiocytes with emphasis on ductular bile formation as well as the clinical consequences of abnormal CFTR, namely CF-associated liver disease. Data on the pathogenesis, prevalence, clinical course, and treatment of CF liver disease will be reviewed.

show abstract

“…It channels the pancreatic and bile secretions while producing electrolytes and fluid (Chenderovitch, 1972;Schulz, 1987). It further controls the drainage of the pancreatic-bile fluid by acting on the muscle sphincter of the duct wall (Byrnes et al, 1981;Keane et al, 1981;Adami et al, 1986;Dahlstrand et al, 1990;Milenov et al, 1990;Binmoeller et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Development of the endocrine cells in the rat pancreatic and bile duct system

Park

Bendayan

1993

Histochem J

View full text Add to dashboard Cite

Morphological features of the endocrine cells in the duct system of the pancreas and the biliary tract have been recently characterized in the adult animal with respect to their physiological roles. In the present study, we have investigated their chronological appearance as well as their developmental progress at various stages of the rat fetal and postnatal life. On day 12 of gestation, glucagon and insulin, as well as CCK cells, were identified in the pancreatic primordium. On day 14, glucagon and CCK cells were first detected in the epithelial lining of the common hepatic and the hepatic ducts. These cells remained the dominant endocrine type in the duct system during the fetal period. Insulin and pancreatic polypeptide cells were first observed in the common hepatic duct only on days 16 and 18 of gestation respectively. In spite of their presence in the islets, somatostatin cells were not detected in the duct system during fetal life. They started to appear in the accessory pancreatic duct of the neonate, and subsequently in the common hepatic duct as well as in the small pancreatic ones on day 7 after birth. During postnatal development, the endocrine cells showed progressive or retrogressive changes in different portions of the duct system according to the cell type. In general, somatostatin, CCK and pancreatic polypeptide cells showed an increase, while glucagon and insulin cells gradually dwindled in number up to the adult stage. Somatostatin cells exhibited a significant increase in number, becoming the highest population among the duct endocrine cells in the adult. Throughout the developmental progress, the endocrine cells appear to be allocated in regions relevant to their possible influence modulating the exocrine secretion as well as the drainage of the pancreatic and bile fluid.

show abstract

Secretory function of the rabbit common bile duct

Cited by 37 publications

References 0 publications

Regulation of cholangiocyte bicarbonate secretion

Regulation of cholangiocyte bicarbonate secretion

Cholangiocyte Biology and Cystic Fibrosis Liver Disease

Development of the endocrine cells in the rat pancreatic and bile duct system

Contact Info

Product

Resources

About