2005
DOI: 10.3748/wjg.v11.i45.7097
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Secretory expression and characterization of a recombinant-deleted variant of human hepatocyte growth factor inPichia pastoris

Abstract: The P pastoris system represents an attractive tool of generating large quantities of hdHGF for both research and industrial purposes.

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Cited by 5 publications
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“…The generation of rcHGF was higher than the previously reported production of rhHGF using insect (Wang et al, 2000;Yee et al, 1993) or mammalian cells (Nakamura et al, 1989). The use of other production systems, for instance the yeast Pichia pastoris (Liu et al, 2005) may yield even higher quantities of >500 mg/L recombinant HGF. When the effects of post-transcriptional modifications such as glycosylation (Fukuta et al, 2005) are fully known in vivo, the use of other production systems, such as non-eukaryotic cells may offer a tool for mass production of rcHGF.…”
Section: Discussionmentioning
confidence: 47%
“…The generation of rcHGF was higher than the previously reported production of rhHGF using insect (Wang et al, 2000;Yee et al, 1993) or mammalian cells (Nakamura et al, 1989). The use of other production systems, for instance the yeast Pichia pastoris (Liu et al, 2005) may yield even higher quantities of >500 mg/L recombinant HGF. When the effects of post-transcriptional modifications such as glycosylation (Fukuta et al, 2005) are fully known in vivo, the use of other production systems, such as non-eukaryotic cells may offer a tool for mass production of rcHGF.…”
Section: Discussionmentioning
confidence: 47%