Secretory effects of VIP on isolated perfused porcine pancreas.

Jensen, S. L.; Fahrenkrug, Jan; Holst, Jens J.; Nielsen, O.B.; Muckadell, Ove B. Schaffalitzky de

doi:10.1152/ajpendo.1978.235.4.e387

Cited by 43 publications

(28 citation statements)

References 16 publications

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“…The level of cholecystokinin also increased ; in its sulfated octapeptide form this product is a regulatory peptide of pancreatic enzyme secretion in pigs (Jensen et al, 19811 Chayvialle et al (1980). It is known that VIP is mainly a neurotransmitter (Larsson et al, 1978) and that in pigs it has less effect on pancreatic secretion than does secretin (Jensen et al, 1978b). According to Fahrenkrug (1979), local reflexes may initiate VIP-mediated increases in blood flow.…”

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Short-term (8-day) effects of a raw soybean diet on exocrine pancreatic secretion and plasma gastrointestinal hormone levels in the pig

Corring¹,

Gueugneau²,

Chayvialle³

et al. 1986

Reprod. Nutr. Dévelop.

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Summary. The aim of the present study was to investigate the short-term (8-day) effects of feeding a raw soybean diet on exocrine pancreatic secretion and the plasma levels of gastrointestinal hormones in pigs. After adaptation to a heated soybean diet, 6 pigs (36.5 + 0.8 kg) were fitted with permanent fistulae of the pancreatic duct, the duodenum and a carotid artery. After post-surgical recovery of 8 days, the animals were submitted to two experimental periods, a 4-day period during which they were fed the heated soybean diet and an 8-day period during which they received the raw soybean diet. Exocrine pancreatic secretion and plasma levels of secretin, cholecystokinin, VIP, PP, somatostatin and gastrin were monitored each day of the two experimental periods.On the first day of raw soybean ingestion and till its end, the daily volume of pancreatic juice was higher than the mean volume measured during heated soybean ingestion. On the contrary, daily total protein output was unchanged. Specific activies of chymotrypsin, amylase and lipase were not modified by the raw soybean diet whereas, from the third day of the experimental period, that of trypsin was higher than the corresponding mean value determined during the first experimental period. Plasma levels of secretin and VIP were higher throughout raw soybean ingestion than the corresponding mean levels determined during the first experimental period. The plasma level of cholecystokinin increased only slightly and in the first days of the second experimental period only. The other gastrointestinal hormones studied were slightly (gastrin) or not (somatostatin, PP) affected by raw soybean feeding.It is suggested that feedback control of exocrine pancreatic secretion in pigs was the mechanism involved in the increase of pancreatic juice observed when raw soybean was fed. This volume increase would result from secretin release into the blood.Introduction.

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Short-term (8-day) effects of a raw soybean diet on exocrine pancreatic secretion and plasma gastrointestinal hormone levels in the pig

Corring¹,

Gueugneau²,

Chayvialle³

et al. 1986

Reprod. Nutr. Dévelop.

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“…This allowed a classification of VIP-secretin receptors into three subtypes: (1) VlP-preferring receptors; (2) high-affinity secretin receptors, and (3) low-affinity secretin receptors. The properties of secretin at high-affinity secretin receptors were likely to reflect a contribution of membranes from centroacinar and duct cells.Secretin and vasoactive intestinal peptide (VIP) stimulate the pancreatic exocrine secre tion with variable relative efficacy and po tency in several animal species [6,12,13,19,21], The predominant response is, in general, a water and bicarbonate hypersecretion that originates, at least partially, from centroaci nar and duct cells [7], In rat and guinea pig, secretin and VIP also elicit the secretion of hydrolases in vriro [5,24,26] indicating an added direct effect of both peptides on pan creatic acinar cells.The VIP-secretin receptors of pancreatic acinar cells from guinea pig have been exten sively characterized [4,10,25]. 'VIP-preferring receptors' are distinct from 'secretin-pre ferring receptors' and appear to be associated with the secretory effect of both peptides [ 10].…”

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Characterization of Secretin and Vasoactive Intestinal Peptide Receptors in Rat Pancreatic Plasma Membranes Using the Native Peptides, Secretin-(7–27) and Five Secretin Analogues

Robberecht¹,

Waelbroeck²,

Noyer³

et al. 1982

Digestion

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A comparison has been made of the ability of vasoactive intestinal peptide (VIP), secretin, secretin analogues, and secretin-(7–27) to stimulate adenylate cyclase in rat pancreatic plasma membranes. A parallel study of the capacity of peptides of the VIP-secretin family to compete with ¹²⁵I-VIP for binding to the same plasma membranes was conducted. This allowed a classification of VIP-secretin receptors into three subtypes: (1) VIP-preferring receptors; (2) high-affinity secretin receptors, and (3) low-affinity secretin receptors. The properties of secretin at high-affinity secretin receptors were likely to reflect a contribution of membranes from centroacinar and duct cells.

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“…Thus VIP may exert its action by release from nerve terminals, and the VIP level in the venous plasma may represent an overflow (Jensen et al, 1978). The VIP level in the venous plasma in the anaesthetized and atropinized cat was raised up 0.27 nm after vagus nerve stimulation , and this level induced a moderate increase in pancreatic juice flow in the isolated and perfused kitten pancreas.…”

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confidence: 97%

A Comparison of Secretory Actions of VIP, Secretin and CCK-PZ in the Isolated and Perfused Kitten Pancreas

Kanno

Saito

1980

Endocrinol Japon

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SynopsisSecretory actions of VIP (vasoactive intestinal peptide), secretin and CCK-PZ (Cholecystokinin-pancreozymin) were compared in the isolated and perfused kitten pancreas.Perfusion of the isolated kitten pancreas with a solution containing 20 mU/ml CCK-PZ resulted in gradual hyperpolarization of the pancreatic acinar cell. CCK-PZ induced a dose-dependent increase in the pancreatic protein output and a small but definite increase in the flow of pancreatic juice which was also dose dependent upon CCK-PZ.Secretin and VIP induced a dose-dependent increase in the flow but a negligible increase in the pancreatic protein output.The estimated ED50 for VIP was 1.5 nM which was 5 times as large as the estimated ED50 for secretin. A considerable amount of VIP, which corresponded roughly to the activity of exogenous 0.6 nM VIP, was spontaneously released from the isolated kitten duodenum into the portal vein, and this VIP release was nullified during vascular perfusion with a Ca-deficient solution.With respect to these and other results, we will propose a view concering a possible role of VIP in controlling the function of the execrine pancreas.

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Secretory effects of VIP on isolated perfused porcine pancreas.

Cited by 43 publications

References 16 publications

Short-term (8-day) effects of a raw soybean diet on exocrine pancreatic secretion and plasma gastrointestinal hormone levels in the pig

Short-term (8-day) effects of a raw soybean diet on exocrine pancreatic secretion and plasma gastrointestinal hormone levels in the pig

Characterization of Secretin and Vasoactive Intestinal Peptide Receptors in Rat Pancreatic Plasma Membranes Using the Native Peptides, Secretin-(7–27) and Five Secretin Analogues

A Comparison of Secretory Actions of VIP, Secretin and CCK-PZ in the Isolated and Perfused Kitten Pancreas

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