Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature

Desai, Megan A.; Mehrad, Mitra; Ely, Kim; Bishop, Justin A.; Netterville, James L.; Aulino, Joseph M.; Lewis, James S.

doi:10.1007/s12105-018-0995-2

Cited by 24 publications

(7 citation statements)

References 39 publications

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“…As a member of the new classification of salivary gland malignant tumors, it was officially listed in the WHO Head and Neck Tumor Classification (4 th edition) and referred to as secretory carcinoma. SCSGs of other organs have also been reported, such as the minor salivary glands around the sinuses ( 7 ), lips ( 8 ), and buccal mucosa ( 9 ), as well as the thyroid gland ( 10 ) and lungs. It often presents as a cystic-solid mass and the boundary is not clear.…”

Section: Discussionmentioning

confidence: 99%

Two cases report of secretory carcinoma of the salivary gland in the lung: one primary and one metastatic after many years

Wang¹,

Xie²,

Li³

et al. 2022

Gland Surg

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Background: Secretory carcinoma of the salivary gland (SCSG) is a recently discovered salivary gland tumor that occurs mostly in the major salivary glands and occasionally in the skin, cervix, trachea, etc.Secretory carcinoma of the lung is extremely rare. To our knowledge, this is the third report of SCSG arising as a primary pulmonary tumor. The two SCSG cases reported in this paper are unique in that one was primary and the other was metastasized to the lung.Case Description: Case 1 is a primary endobronchial tumor in a 66-year-old man. He went to the doctor complaining of fever, cough and yellow phlegm, and his body weight was significantly reduced by 3 kg. The bronchoscope showed the growth of new organisms in the right upper lobe of the lung.Immunohistochemistry of his biopsy specimen was positive for AE1/AE3, Keratin7 (CK7), S-100, mammaglobin, and pan-TRK, but negative for thyroid transcription factor-1 (TTF-1), napsin-A, synaptophysin (SYN), chromogranin A (CGA), and discovered on GIST-1 (Dog-1), and the MKI-67 (Ki-67) proliferation index was 2%. This case lacked the typical ETV-6 gene rearrangement. After one cycle of chemotherapy, the tumor was significantly reduced, and surgical excision was planned. Case 2 was a metastatic secretory carcinoma with a history of parotid pleomorphic adenoma resection 30 years ago and malignant pleomorphic adenoma resection 16 years ago before the study, respectively. He presented with a complaint of a parotid gland mass. Chest CT examination revealed a mass in the upper lobe of the left lung. The biopsy tissue of him exhibited a typical histological appearance under the microscope.Immunohistochemistry was positive for AE1/AE3, CK7, S-100, and mammaglobin; partially positive for estrogen receptor (ER) and pan-TRK; and negative for TTF-1, Napsin-A, SYN, CGA, P63, P40, and Dog-1. The Ki-67 proliferation index was approximately 3%. Fluorescence in situ hybridization (FISH) revealed ETV-6 gene rearrangement. After the diagnosis of SCSG, the patient underwent resection of the lung mass, and there was no recurrence of the lung after 1 month's follow-up. Conclusions: By examining these two cases, we have a better understanding of the clinicopathological features of secretory carcinoma, which will help to improve the accuracy of pathological diagnosis.

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Section: Discussionmentioning

confidence: 99%

Two cases report of secretory carcinoma of the salivary gland in the lung: one primary and one metastatic after many years

Wang¹,

Xie²,

Li³

et al. 2022

Gland Surg

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“…Classically, the junction is between Exon 5 of ETV6 and Exon 15 of NTRK3. Since the original series, SC has been subsequently reported in non-salivary gland sites such as skin, thyroid gland, eyelid, lung, as well as in the sinonasal tract [5][6][7][8][9][10]. Recently, bona fide salivary gland SC with ETV6-RET and ETV6-MET translocations have been described, thus expanding the molecular profile of SC beyond the ETV6-NTRK3 translocation [11,12].…”

Section: Introductionmentioning

confidence: 99%

(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4–Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing

Loh

Vaněček

et al. 2019

Head and Neck Pathol

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We present a 72 years old male with a left nasal cavity (mammary analogue) secretory carcinoma (SC) which exhibited classical morphological features on light microscopical examination, diffuse strong S100 and mammoglobin positivity on immunohistochemistry, and ETV6-NTRK3 gene fusion on next generation sequencing (NGS) analysis. Unusual features of this tumor are expression of p63 and DOG1 on immunohistochemistry and the atypical junction between Exon 4 of the ETV6 gene and Exon 14 of the NTRK3 gene.

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“…It has been reported that this type of carcinoma can arise in the salivary glands, thyroid gland, lacrimal glands, and the skin 6‐8 . Fusion genes other than ETV6‐NTRK3 have been reported in secretory carcinomas of different organs, including ETV6‐RET , ETV6‐MET , and the dual fusion of ETV6‐NTRK3 and ETV6‐MAML3 6,7,9‐12 …”

Section: Discussionmentioning

confidence: 99%

Secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs: A case report

et al. 2021

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Secretory carcinoma of the skin is an extremely rare adnexal tumor, histopathologically identical to homologous lesions in the salivary glands and breast tissue. Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, a 31‐year‐old women, had a subcutaneous mass in the right axilla. The resected specimen contained a circumscribed mass, with proliferating tumor cells that exhibited prominent nucleoli. They exhibited glandular and papillary growth patterns and there were amphophilic secretions in the glands. Immunohistochemically, the tumor cells were positive for mammaglobin and S100. The tumor was surrounded by sweat glands and there was no mammary glandular tissue, suggesting that it was derived from axillary sweat glands. Accordingly, we made a diagnosis of secretory carcinoma of the skin. Four years after the operation, there were metastases in both lungs. The resected specimen revealed a tumor identical to that of the original skin tumor. Next‐generation sequencing‐based multiplex gene assay performed on the metastatic tissue revealed an ETV6‐NTRK3 fusion gene. This is a rare case report of secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs.

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Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature

Cited by 24 publications

References 39 publications

Two cases report of secretory carcinoma of the salivary gland in the lung: one primary and one metastatic after many years

Two cases report of secretory carcinoma of the salivary gland in the lung: one primary and one metastatic after many years

(Mammary Analogue) Secretory Carcinoma of the Nasal Cavity: Report of a Rare Case with p63 and DOG1 Expression and Uncommon Exon 4–Exon 14 ETV6-NTRK3 Fusion Diagnosed with Next Generation Sequencing

Secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs: A case report

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