Secretory Carcinoma in Children and Young Adults: A Case Series

Simon, Caroline T.; McHugh, Jonathan B.; Rabah, Raja; Heider, Amer

doi:10.1177/10935266211046996

Cited by 2 publications

(3 citation statements)

References 18 publications

(31 reference statements)

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“…Therefore, we can speculate that male SBC is more likely to occur at a younger age than is female SBC. Notably, in the small series composed exclusively of pediatric and adolescent patients, males also were the majority among pediatric patients with predominantly low-grade and early-stage tumors (12). Interestingly, the incidence of SBC has been declining in recent decades, which may be related to the reduction of the misdiagnosis rate resulting from the enhanced understanding of SBC and the improvement of diagnostic technology (8).…”

Section: Demographic Characteristicsmentioning

confidence: 99%

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Advancement of secretory breast carcinoma: a narrative review

Min¹,

Zhu²,

Liu³

et al. 2022

Ann Transl Med

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Background and Objective: Secretory breast carcinoma (SBC) is a rare breast malignancy. Most available studies on SBC are case reports or small case series, and the few large-sample studies available lack critical information due to database limitations. To improve the understanding of SBC and provide a reference for clinical practice, we systematically reviewed the demographic, clinical, pathologic, and genetic characteristics of SBC, as well as its treatment and prognosis.Methods: We conducted a PubMed search with the keywords "secretory breast carcinoma" or "juvenile breast carcinoma". Relevant English-language publications published from January 1966 to February 2022 were screened manually at 3 levels-title, abstract, and full text-to identify the articles that presented the demographic, clinical, pathologic, and genetic characteristics of SBC, as well as its treatment and prognosis.Key Content and Findings: SBC lacks specific clinical manifestations and has typical pathological and molecular characteristics, including intracellular and extracellular eosinophilic secretions, immune spectrum similar to hormone receptor-positive tumors, and the ETV6-NTRK3 fusion gene. Surgery remains the primary treatment for SBC. Postoperative radiotherapy is recommended by most researchers for adult SBC but not for pediatric patients. The evidence of chemotherapy and endocrine therapy is insufficient, and targeted therapy of the ETV6-NTRK3 fusion gene shows a good response. Most patients with SBC have a good prognosis except for a few patients who experience distant metastases. Future studies will be focused on the molecular characteristics of those patients with SBC who have a poor prognosis. Conclusions:The development of histopathology and molecular genetics has promoted the progress of the clinical diagnosis of SBC. The purpose of this review is to serve as a guide for the better clinical treatment of SBC, particularly in the areas of disease identification and prognosis classification for patients.

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Section: Demographic Characteristicsmentioning

confidence: 99%

Section: Demographic Characteristicsmentioning

confidence: 99%

Advancement of secretory breast carcinoma: a narrative review

Min¹,

Zhu²,

Liu³

et al. 2022

Ann Transl Med

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“…Out of a total of 226 studies published between 2010 and 2023, identified at initial search and screened for retrieval, 112 1–3,6–114 articles were included in the study, with a total of 674 patients described in these articles. The identification and screening process is described in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

Yosefof,

Boldes,

Dan

et al. 2023

The Laryngoscope

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ObjectivesSecretory Carcinoma is a malignant salivary gland tumor, initially described in 2010. This rare tumor is associated with the translocation t(12;15) (p13;q25), resulting in the fusion gene ETV6‐NTRK3. Since this tumor is quite rare, most publications describe only small cohorts of patients. We aimed to investigate the clinical, pathological, and prognostic features of this newly defined malignant entity.Data SourcesPubmed, Google Scholar, and Web of Science databases.Review MethodsAll published articles between 2010 and 2023 were reviewed. Search terms included the terms “Mammary Analogue Secretory Carcinoma” and “Secretory Carcinoma”. All articles published in English reporting on Secretory Carcinoma of salivary glands were retrieved.ResultsOne‐hundred and 12 retrospective articles reporting a total of 674 patients were included, with 52% males and a mean age of 44.9 ± 18.9. The event rate for patients with advanced‐stage disease (Stage 3/4) at presentation was 24.1% (95% CI 17.6%–31.9%, I2 = 9.2%), 14.6% for regional metastases (95% CI 10.5%–20%, I2 = 12%), and the event rate of distant metastasis was 8.4% (95% CI 5.5%–12.7%, I2 = 4.2%). Adjuvant radiotherapy was administered for 30.3% of patients (95% CI 24.1%–37.2%, I2 = 21.5%). The recurrence rate was 19% (95% CI 15.1%–23.8%, I2 = 5%). Survival outcomes showed a 17.2% death of disease rate for Secretory Carcinoma patients (95% CI 13.5%–21.8%, I2 = 7.3%).ConclusionsSecretory Carcinoma is a rare and relatively newly defined entity arising in the parotid gland most commonly. Characterized as a low‐grade tumor, the majority of patients are diagnosed at an early stage, without regional or distant disease, and the prognosis is relatively good.Level of EvidenceN/A Laryngoscope, 2023

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Secretory Carcinoma in Children and Young Adults: A Case Series

Cited by 2 publications

References 18 publications

Advancement of secretory breast carcinoma: a narrative review

Advancement of secretory breast carcinoma: a narrative review

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

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