Secretory breast carcinoma in a female adult with liver metastsis: a case report and literature review

Lian, Jing; Wang, Lixia; Guo, Jianghong; Bu, Pengcheng; Xi, Yanfeng; Yun, Keming

doi:10.1186/s13000-021-01156-6

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Tumors >2 cm and more than 3 involved axillary lymph nodes can be used as predictors of distant metastasis (15). According to the review of Lian et al (89), 20 cases of SBC with distant metastases have been described over the last 50 years (15,24,30,66,70,83,(89)(90)(91)(92)(93)(94), with a male to female ratio of 4:11 and an average age of 26 years (range, 8 to 73 years) except for 6 cases with unknown clinical information. Additionally, Tang et al (77) were first to report an SBC case complicated with multiple brain metastases, and the patient eventually died of systemic multiple metastases.…”

Section: Prognosismentioning

confidence: 99%

“…Additionally, Tang et al ( 77 ) were first to report an SBC case complicated with multiple brain metastases, and the patient eventually died of systemic multiple metastases. More generally, for patients with SBC and distant metastases, the median time between diagnosis and metastasis was 25 months (range, 2.5 to 240 months), with most metastases seen in lung (9 cases), liver (5 cases), and bone (4 cases) ( 89 ), and the mean survival time after the initial diagnosis was 74.6 months (range, 6 to 240 months) ( 77 ).…”

Section: Treatment and Prognosismentioning

confidence: 99%

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Advancement of secretory breast carcinoma: a narrative review

Min¹,

Zhu²,

Liu³

et al. 2022

Ann Transl Med

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Background and Objective: Secretory breast carcinoma (SBC) is a rare breast malignancy. Most available studies on SBC are case reports or small case series, and the few large-sample studies available lack critical information due to database limitations. To improve the understanding of SBC and provide a reference for clinical practice, we systematically reviewed the demographic, clinical, pathologic, and genetic characteristics of SBC, as well as its treatment and prognosis.Methods: We conducted a PubMed search with the keywords "secretory breast carcinoma" or "juvenile breast carcinoma". Relevant English-language publications published from January 1966 to February 2022 were screened manually at 3 levels-title, abstract, and full text-to identify the articles that presented the demographic, clinical, pathologic, and genetic characteristics of SBC, as well as its treatment and prognosis.Key Content and Findings: SBC lacks specific clinical manifestations and has typical pathological and molecular characteristics, including intracellular and extracellular eosinophilic secretions, immune spectrum similar to hormone receptor-positive tumors, and the ETV6-NTRK3 fusion gene. Surgery remains the primary treatment for SBC. Postoperative radiotherapy is recommended by most researchers for adult SBC but not for pediatric patients. The evidence of chemotherapy and endocrine therapy is insufficient, and targeted therapy of the ETV6-NTRK3 fusion gene shows a good response. Most patients with SBC have a good prognosis except for a few patients who experience distant metastases. Future studies will be focused on the molecular characteristics of those patients with SBC who have a poor prognosis. Conclusions:The development of histopathology and molecular genetics has promoted the progress of the clinical diagnosis of SBC. The purpose of this review is to serve as a guide for the better clinical treatment of SBC, particularly in the areas of disease identification and prognosis classification for patients.

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Section: Prognosismentioning

confidence: 99%

Section: Treatment and Prognosismentioning

confidence: 99%

Advancement of secretory breast carcinoma: a narrative review

Min¹,

Zhu²,

Liu³

et al. 2022

Ann Transl Med

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“…Tumor size in SBC is a prognostic indicator. Indeed, a median size of 5.3 cm has been reported in locally advanced tumors, exceeding the dimensions typically observed in other breast cancer subtypes [ 11 ]. This particularity may explain the frequent initial confusion of SBC with benign lesions.…”

Section: Discussionmentioning

confidence: 99%

Secretory Carcinoma of the Breast: A Rare Entity With Favorable Prognosis

Margoum,

Berhili,

Bouabid

et al. 2024

Cureus

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Secretory breast carcinoma (SBC) is an extremely rare entity of breast cancer, which can affect all age groups. The diagnosis is based on the characteristic microscopic appearance, and despite the triple negativity or low hormone receptor positivity, SBC is generally characterized by a favorable prognosis. Due to the rarity of the disease, no clear consensus on optimal treatment is available. Nevertheless, conservative surgery or mastectomy is the main therapeutic option. The efficacy of chemotherapy, radiotherapy, and hormone therapy in this pathology has not been rigorously explored. We report the case of a 65-year-old woman with SBC treated with surgery and adjuvant radiotherapy, with a review of the literature.

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“…There are no established guidelines dictating the extent of surgical excision. Due to the reduced metastatic capacity of the tumor, total axillary lymphadenectomy is under debate and the extent of lymph node dissection varies depending on the clinical presentation [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Secretory Carcinoma of the Breast Mimicking Invasive Ductal Carcinoma: A Case Report

et al. 2022

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Patient: Female, 40-year-old Final Diagnosis: Secretory breast carcinoma Symptoms: Breast mass Medication:— Clinical Procedure: — Specialty: Oncology Objective: Rare disease Background: Secretory breast carcinoma (SBC), an extremely rare malignancy, is related to a chromosomal translocation which leads to an ETV6-NTRK3 fusion mutation. SBC is characterized by eosinophilic secretions and is usually triple-negative, with a small number of patients demonstrating ER-positivity of the tumors. Diagnosis can be challenging and requires genomic testing for confirmation. Case Report: A 40-year-old woman presented with a breast mass found on mammography. She underwent an ultrasound-guided biopsy of the tumor. Initial pathology evaluation revealed features consistent with invasive ductal carcinoma. The immunochemistry report described an ER-positive, PR-negative, and HER2-negative tumor. The specimen was sent for oncotype scoring, which was not performed due to the specimen not meeting the criteria for invasive ductal carcinoma and displaying pathological features of SBC. A fluorescent in situ hybridization (FISH) study revealed ETV6 translocation, consistent with the diagnosis of SBC. The patient underwent lumpectomy followed by adjuvant radiotherapy and endocrine therapy. She remains in complete remission 3 years after treatment. Conclusions: Accurately diagnosing SBC is of extreme importance as it has an indolent clinical course, but has a favorable prognosis if detected early. Due to nonspecific imaging findings, pathology evaluation with immunohistochemical staining followed by genomic testing is required. Our case highlights the challenges associated with SBC diagnosis requiring genomic testing due to equivocal pathological findings, along with increasing incidence of SBT in adults. There are no established guidelines for SBC management . The mainstay of treatment is partial or total mastectomy. Data on the benefits of adjuvant endocrine therapy, chemotherapy, and radiotherapy are inconclusive.

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Secretory breast carcinoma in a female adult with liver metastsis: a case report and literature review

Cited by 8 publications

References 25 publications

Advancement of secretory breast carcinoma: a narrative review

Advancement of secretory breast carcinoma: a narrative review

Secretory Carcinoma of the Breast: A Rare Entity With Favorable Prognosis

Secretory Carcinoma of the Breast Mimicking Invasive Ductal Carcinoma: A Case Report

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