Secretory activity of subcutaneous abdominal adipose tissue in male patients with rheumatoid arthritis and osteoarthritis – association with clinical and laboratory data

Kontny, Ewa; Zielińska, Agnieszka; Księżopolska-Orłowska, Krystyna; Głuszko, Piotr

doi:10.5114/reum.2016.63662

Cited by 12 publications

(10 citation statements)

References 29 publications

(52 reference statements)

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“…Moreover, some [21, 30], but not all [22, 31], studies have demonstrated that anti-TNF-α therapy in RA was associated with an increase in serum adiponectin levels. A few studies suggested that the level of serum adiponectin in RA is related to disease duration [15, 32]. In this respect, we have observed that serum adiponectin levels correlated with CRP only in patients with RA duration ≥ 8 years.…”

Section: Discussionsupporting

confidence: 48%

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis

Sikorska¹,

Rutkowski²,

Łuczak³

et al. 2018

cejoi

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IntroductionWhile adiponectin is typically viewed as an anti-inflammatory mediator, such an activity of adiponectin in rheumatoid arthritis (RA) is not so obvious. In the present study we examined whether serum levels of adiponectin reflect the clinical phenotype of RA patients and/or correlate with severity of the disease and the response to anti-TNF-α therapy.Material and methodsTwenty-one female RA patients qualified to receive anti-TNF-α treatment were prospectively assessed before and after 12 weeks of therapy. Patients underwent full clinical and biochemical assessment. Disease activity was assessed by the Modified Disease Activity Scores (DAS28). Serum concentrations of adiponectin were measured with an immunoassay. The individuals were divided into two subgroups according to whether their baseline serum adiponectin was below or above the median value. The subgroups did not differ in basic demographic, anthropometric, and clinical parameters.ResultsAnti-TNF-α treatment resulted in a significant clinical (DAS28) improvement in patients from both subgroups, but no significant differences between basal and post-treatment serum adiponectin concentrations were observed. However, patients with higher baseline adiponectin experienced a significant and more pronounced improvement in laboratory parameters of inflammation (ESR, CRP, neutrophil count, neutrophil-to-lymphocyte ratio).ConclusionsIt is possible that adiponectin exerts systemic anti-inflammatory effects independently of the local activity of RA.

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Section: Discussionsupporting

confidence: 48%

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis

Sikorska¹,

Rutkowski²,

Łuczak³

et al. 2018

cejoi

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“…Besides serum levels, synovial fluid concentrations of adiponectin are increased in RA [17,71]. In RA patients, subcutaneous abdominal adipose tissue has been found to secrete more adiponectin compared to subcutaneous abdominal adiposetissue from OA patients, and the amount of adiponectin secreted from this tissue positively correlated with the 28-joint disease activity score (DAS28) and disease duration [72].…”

Section: Adiponectinmentioning

confidence: 99%

The Adipokine Network in Rheumatic Joint Diseases

Carrión

Frommer

Pérez‐García

et al. 2019

IJMS

134

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Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irreversible disability when patients are unsuccessfully treated. Although the specific causes of many rheumatic conditions remain unknown, it is generally accepted that immune mechanisms and/or uncontrolled inflammatory responses are involved in their etiology and symptomatology. In this regard, the bidirectional communication between neuroendocrine and immune system has been demonstrated to provide a homeostatic network that is involved in several pathological conditions. Adipokines represent a wide variety of bioactive, immune and inflammatory mediators mainly released by adipocytes that act as signal molecules in the neuroendocrine-immune interactions. Adipokines can also be synthesized by synoviocytes, osteoclasts, osteoblasts, chondrocytes and inflammatory cells in the joint microenvironment, showing potent modulatory properties on different effector cells in OA and RA pathogenesis. Effects of adiponectin, leptin, resistin and visfatin on local and systemic inflammation are broadly described. However, more recently, other adipokines, such as progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin, have been recognized to display immunomodulatory actions in rheumatic diseases. This review highlights the latest relevant findings on the role of the adipokine network in the pathophysiology of OA and RA.

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“…In humans, ScAT of the abdomen, often described as subcutaneous abdominal adipose tissue (SAAT), is routinely subjected to medical examination. SAAT explants stimulated with IL-1b could significantly produce high levels of pro-and antiinflammatory cytokines in patients with OA 15 , suggesting that SAAT could contribute to the inflammatory pathogenesis of knee OA. Furthermore, excessive SAAT may also increase knee joint loading and impulse 16 , indicating that it may also cause knee OA through biomechanical mechanisms.…”

Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

Systemic and local adipose tissue in knee osteoarthritis

Chang

Liao

et al. 2018

Osteoarthritis and Cartilage

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Knee osteoarthritis (OA) is the most common joint disease. Body adipose tissue has been shown to be related to the development and progression of knee OA. Among systemic adipose tissues, subcutaneous adipose tissue is significantly and negatively associated with muscle mass and forces, and could be related to the presence and progression of knee OA. Visceral adipose tissue is associated with increased cartilage loss and production of pro-inflammatory cytokines. Intra-muscular adipose tissue is associated with knee osteoarthritic changes, but it remains controversial if inter-muscular adipose tissue has a role to play in the pathogenesis for knee OA. Knee local adipose tissue such as infrapatellar fat pad (IPFP) can interact with neighbouring tissues, and may have a biphasic effect in knee OA. The underlying mechanisms for the roles of the systemic and local fat in knee OA could be related to biomechanical, metabolic, inflammatory factors and fat fibrosis, which may have a separated or combined effect on OA. Tissue engineering from systemic or local adipose tissue is a new research direction, and adipose tissue-derived stem cells from systemic or local adipose tissue may be beneficial for OA cartilage repair. Research on systemic and local adipose tissue would provide novel approaches for prevention and treatment of knee OA, but further studies are required to explore the roles of different adipose tissues in knee OA and the effects of stem cells derived from different adipose tissues on knee OA.

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Secretory activity of subcutaneous abdominal adipose tissue in male patients with rheumatoid arthritis and osteoarthritis – association with clinical and laboratory data

Cited by 12 publications

References 29 publications

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis

The Adipokine Network in Rheumatic Joint Diseases

Systemic and local adipose tissue in knee osteoarthritis

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