Secretion rate of dehydroepiandrosterone and dehydroepiandrosterone sulfate in benign essential hypertension as compared to normal subjects

Abstract

A study of the secretion rate of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in normal subjects and patients with benign essential hypertension by a double isotope dilution method showed a fivefold increase in the secretion rate of dehydroepiandrosterone (from 9.8 mg/day ± 3.1 mg/day S.D. to 52.0 mg/day ± 15.5 mg/day S.D.), and a sixfold increase of dehydroepiandrosterone sulfate in hypertensive patients (from 10.7 mg/day ± 2.9 mg/day S.D. to 60.7 mg/day ± 18.6 mg/day S.D.). This study was carried out following the administration of 14C-labelled DHEA and 3H-labelled DHEA-S and involved an initial column chromatographic separation of urinary DHEA-glucuronide and sulfate.

Effects of ACTH on Plasma Levels of Adrenal Steroids in Essential Hypertension

“…Japon. June 1976 There have been numerons reports on various abnormalities in steroid metabolism in essential hypertension (EH) (Cooper et al, 1958;Genest et al, 1960;Vermeulen and Van der Straeten, 1963;Shao et al, 1970;Melby et al,1971;Brown et al, 1972;Melby et al, 1972;Mendelsohn et al, 1972;Nowaczynski et al, 1972 a and b;Sasaki et al, 1972;Sekihara et al, 1973;Grim et al, 1974;Nowaczynski et al, 1975). However, in many of these studies, steroids have not been investigated systematically and also, steroids other than aldosterone have not commanded much attention.…”