Secretion of intestinal goblet cells: A novel excretion pathway of nanoparticles

Contact-dependent transfer of TiO2nanoparticles between mammalian cells

“…Transfer of cellular material has also been demonstrated to occur via extracellular vesicular carriers, such as microvesicles or exosomes (Fruhbeis et al, 2013;Raposo & Stoorvogel, 2013). It is important to note here that transcytosis of NPs has been demonstrated for specialised cell types like the intestinal goblet- (Zhao et al, 2013) or M-cells (Des Rieux et al, 2007) and that renal clearance has been shown to be possible for very small particles (Choi et al, 2007;Singh et al, 2006). In the present study, we, however, conclude that the transfer of TiO 2 NPs is not a result of large-scale particle exocytosis but a specific phenomenon dependent on cellular contact based on the following observations: (i) NPs co-transfer (Figures 3c and d and 4a-e) as well as partially co-localise in acceptor cells (Figure 4f) with DiD whose transmission we ( Figure S4a) and others show to be contact dependent (Gurke et al, 2008).…”

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

“…Nanoscale drug delivery systems (NDDS) have shown physical, chemical, pharmacokinetic, and pharmacodynamics properties, which give them advantages when compared with conventional pharmaceutical preparations in the treatment of malignant tumors. [13][14][15] Active carbon nanoparticles (ACNP) have been used as an indicator of lymphatic circulation 16 and act as a sustainedrelease drug delivery carrier 17,18 with low toxicity 19,20 and a large drug loading (DL) capacity due to their graphene composition. [21][22][23] ACNP have been shown to have a constant rate of drug delivery and long drug half-life with effective drug delivery to their target tissues, especially to lymphatic tissues.…”

Translational radionanomedicine: a clinical perspective

“…This was different from excretion of another radiolabeled nanoparticle after the capsular detachment from the nanoparticles (83). As a different excretion pathway, direct excretion from intestines mediated by goblet cells was also reported, not mediated by hepatobiliary excretion (84). Due to this complexity of in vivo distribution and excretion of nanoparticles which might even vary between individuals according to the types of nanoparticles, an individualized distribution study is required to consider the future clinical application.…”