Secretion of Atrial Peptides and Renal Response to Blood Volume Expansion in Rats with Puromycin Aminonucleoside (PAN) Nephrosis

Keeler, R.; Feuchuk, D.; Wilson, Nancy

doi:10.1097/00005344-198611000-00161

Journal of Cardiovascular Pharmacology

1986

DOI: 10.1097/00005344-198611000-00161

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Secretion of Atrial Peptides and Renal Response to Blood Volume Expansion in Rats with Puromycin Aminonucleoside (PAN) Nephrosis

R. Keeler

D. Feuchuk

Nancy Wilson

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1987

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Mechanisms for the release of atrial natriuretic peptide

Aj¹

1987

Can. J. Physiol. Pharmacol.

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In assessing the role that atrial natriuretic peptide (ANP) might have in the homeostasis of fluid volume and blood pressure, it is important to define the physiological and pathophysiological conditions that determine its release into the circulation. There is substantial evidence that ANP is released through atrial distension under a variety of conditions. There are also some indications that ANP may be released through humoral factors, although it is not clear whether this is a result of direct action on the myocytes or simply a result of ensuing haemodynamic changes. There is no evidence to suggest that ANP can be released through stimulation of efferent fibres innervating the atria, but it may be released as a result of changes in myocardial work and oxygen consumption. Plasma levels of ANP are elevated in several disease states and that release appears to be a result of the haemodynamic disturbances in those conditions.

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Mechanisms for the release of atrial natriuretic peptide

Aj¹

1987

Can. J. Physiol. Pharmacol.

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Secretion of Atrial Peptides and Renal Response to Blood Volume Expansion in Rats with Puromycin Aminonucleoside (PAN) Nephrosis

Cited by 1 publication

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Mechanisms for the release of atrial natriuretic peptide

Mechanisms for the release of atrial natriuretic peptide

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