Secretion and Crinophagy in Prolactin Cells

Farquhar, Marilyn G.

doi:10.1007/978-1-4615-6675-5_3

Cited by 96 publications

(32 citation statements)

References 90 publications

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“…Sometimes, RER were lamellated and contained PRL in the cisternae. These findings may support the proposed secretory pathway of PRL by Farquar (1), that is, RER -*Golgi saccules-secretory granules-*extracellular spaces.…”

Section: Applications Of Endocrinology (A) Prolactin In the Rat Pituisupporting

confidence: 84%

Pre-embedding immunoelectron microscopy by peroxidase-labeled antibody method - Applications to endocrinology.

Osamura

Komatsú

Izumi

et al. 1981

Acta Histochem. Cytochem

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Section: Applications Of Endocrinology (A) Prolactin In the Rat Pituisupporting

confidence: 84%

Pre-embedding immunoelectron microscopy by peroxidase-labeled antibody method - Applications to endocrinology.

Osamura

Komatsú

Izumi

et al. 1981

Acta Histochem. Cytochem

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“…GH3 pituitary tumor cells do not normally phosphorylate PRL, but can be induced to do so by incubation in phosphorylated PRL (see later section including autoregulation) or by high concentrations of insulin . Phosphorylation coincides with the formation of initial secretory granules, although these immature secretory granules do not coalesce to form the normal large granules of mammotrophs (Farquhar, 1977).…”

Section: Physiological Regulationmentioning

confidence: 99%

S179D prolactin: Antagonistic agony!

Walker

2007

Molecular and Cellular Endocrinology

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The aims of this review are threefold: First, to collate what is known about the production and activities of phosphorylated prolactin (PRL), the latter largely, but not exclusively, as illustrated through the use of the molecular mimic, S179D PRL; second, to apply this and related knowledge to produce an updated model of prolactin-receptor interactions that may apply to other members of this cytokine super-family; and third, to promote a shift in the current paradigm for the development of clinically important growth antagonists. This third aim explains the title since, based on results with S179D PRL, it is proposed that agents which signal to antagonistic ends may be better therapeutics than pure antagonists -hence antagonistic agony. Since S179D PRL is not a pure antagonist, we have proposed the term selective prolactin receptor modulator (SPeRM) for this and like molecules.

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“…Moi et al (1984) discovered that crinophagy increased in the corticotrophs during states of both hypersecretion due to adrenalectomy and hyposecretion induced by administration of dexamethasone. Thus, in the pituitary gland, crinophagy acts in tandem with natural and induced fluctuations in secretory activity to continuously regulate and maintain proper intracellular levels of secretory protein (Smith & Farquhar 1966, Farquhar 1977.…”

Section: Pituitary Glandmentioning

confidence: 99%

Autophagy in the endocrine glands

Weckman¹,

Ieva²,

Rotondo³

et al. 2014

Journal of Molecular Endocrinology

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Autophagy is an important cellular process involving the degradation of intracellular components. Its regulation is complex and while there are many methods available, there is currently no single effective way of detecting and monitoring autophagy. It has several cellular functions that are conserved throughout the body, as well as a variety of different physiological roles depending on the context of its occurrence in the body. Autophagy is also involved in the pathology of a wide range of diseases. Within the endocrine system, autophagy has both its traditional conserved functions and specific functions. In the endocrine glands, autophagy plays a critical role in controlling intracellular hormone levels. In peptide-secreting cells of glands such as the pituitary gland, crinophagy, a specific form of autophagy, targets the secretory granules to control the levels of stored hormone. In steroid-secreting cells of glands such as the testes and adrenal gland, autophagy targets the steroid-producing organelles. The dysregulation of autophagy in the endocrine glands leads to several different endocrine diseases such as diabetes and infertility. This review aims to clarify the known roles of autophagy in the physiology of the endocrine system, as well as in various endocrine diseases.

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Secretion and Crinophagy in Prolactin Cells

Cited by 96 publications

References 90 publications

Pre-embedding immunoelectron microscopy by peroxidase-labeled antibody method - Applications to endocrinology.

Pre-embedding immunoelectron microscopy by peroxidase-labeled antibody method - Applications to endocrinology.

S179D prolactin: Antagonistic agony!

Autophagy in the endocrine glands

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