Secretin: An Old Hormone with a Burning Secret

Mynatt, Randall L.; Ravussin, Éric

doi:10.1016/j.cell.2018.11.008

Cited by 6 publications

(3 citation statements)

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“…These effects of secretin suggest that secretin could potentially induce negative energy balance and weight loss in rodents and humans. [64]…”

Section: Literature Search Strategymentioning

confidence: 99%

“…These effects of secretin suggest that secretin could potentially induce negative energy balance and weight loss in rodents and humans. [64] The findings presented by Li et al [65] provide us with an incomplete narrative regarding the potential of secretin as a target for weight control in humans. Exploring secretin as a potential tool for managing weight appears logical since it plays a role in facultative meal-induced thermogenesis and promotes satiety.…”

Section: Secretinmentioning

confidence: 99%

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Pancreatic biomarkers: role in diabetes mellitus

Rafaqat,

Hafeez,

Mairaj

et al. 2023

Journal of Pancreatology

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Diabetes mellitus refers to a group of diseases that cause high blood sugar levels. The most common type is type 2 diabetes, which is caused by insulin resistance and inadequate insulin production. However, diabetes can also result from conditions affecting the exocrine pancreas. Both type 1 and type 2 diabetes patients may experience changes in their pancreatic exocrine function, leading to reduced levels of fecal elastase-1 in many cases. This review paper focuses on the role of specific pancreatic biomarkers in diabetes mellitus, including cholecystokinin, trypsin, chymotrypsin, carboxypeptidase, amylase, lipase, secretin, elastase-1, and retinol-binding protein 4 about recent advances and discoveries, significant gaps in the literature, current debates, and potential directions for future research related to these biomarkers about diabetes mellitus. This review article discusses various biomarkers related to pancreatic exocrine and endocrine function and their implications in diabetes. It suggests that gut cholecystokinin may play a role in lowering glucose synthesis through a neural network and resistance to it could contribute to hyperglycemia in diabetic patients. It also discusses the use of various markers such as serum trypsin concentration, amylase and lipase levels, pancreatic elastase levels, and fasting secretin levels to assess pancreatic exocrine function. Additionally, the article explores the role of carboxypeptidase E in the endocrine and neurological systems and its association with disorders. Moreover, it also highlights the involvement of retinol-binding protein 4 in the development of type 2 diabetes and insulin resistance.

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“…These effects of secretin suggest that secretin could potentially induce negative energy balance and weight loss in rodents and humans. [64]…”

Section: Literature Search Strategymentioning

confidence: 99%

Section: Secretinmentioning

confidence: 99%

Pancreatic biomarkers: role in diabetes mellitus

Rafaqat,

Hafeez,

Mairaj

et al. 2023

Journal of Pancreatology

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“…bicarbonate) release [13] to neutralise the duodenal acid load from the stomach. It also has a role in satiety [14], and it may mediate satiety by affecting postprandial thermogenesis via brown fat action [15], at least in mice. In terms of macronutrient effects, there is not much known, but one study showed no effect of a protein rich meal on postprandial blood secretin levels [16].…”

Section: Peptide Hormones From the Alimentary Tractmentioning

confidence: 99%

Role of Peptide Hormones in the Adaptation to Altered Dietary Protein Intake

Rose

2019

Nutrients

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Dietary protein profoundly influences organismal traits ultimately affecting healthspan. While intracellular signalling downstream of altered amino acid supply is undoubtedly important, peptide hormones have emerged as critical factors determining systemic responses to variations in protein intake. Here the regulation and role of certain peptides hormones in such responses to altered dietary protein intake is reviewed.

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