2017
DOI: 10.1523/jneurosci.3632-16.2017
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Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin

Abstract: The secreted glycoprotein Reelin regulates embryonic brain development and adult brain functions. It has been suggested that reduced Reelin activity contributes to the pathogenesis of several neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease; however, noninvasive methods that can upregulate Reelin activity have yet to be developed. We previously found that the proteolytic cleavage of Reelin within Reelin repeat 3 (N-t site) abolishes Reelin activity, but it remains… Show more

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Cited by 62 publications
(66 citation statements)
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“…This may explain why the level of Tau phosphorylation in the embryonic cerebral cortex, which was markedly down-regulated in ADAMTS-3 KO mice 12 , was not significantly affected in KI/KI mice (Fig. 1E).…”
Section: Second Bothmentioning
confidence: 92%
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“…This may explain why the level of Tau phosphorylation in the embryonic cerebral cortex, which was markedly down-regulated in ADAMTS-3 KO mice 12 , was not significantly affected in KI/KI mice (Fig. 1E).…”
Section: Second Bothmentioning
confidence: 92%
“…However, ADAMTS-3 was not the only protease to inactivate Reelin; its cleavage still occurred in the cerebral cortex and hippocampus of 3 ADAMTS-3 KO mice 12 . The neuronal dendrites contained more branches and were elongated in the cerebral cortex of ADAMTS-3 conditional KO mice compared to the control mice 12 . We speculated that this effect was due to decreased Reelin cleavage, but it remained possible that there was a critical ADAMTS-3 substrate(s) that somehow affected dendrite morphology.…”
Section: Introductionmentioning
confidence: 91%
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