Secreted Brain-Derived Neurotrophic Factor and Asthma Severity

Wang, Shengyu; Sathish, Venkatachalem; Freeman, Michele; Thompson, Michael A.; Pabelick, Christina M.; Prakash, Y. S.

doi:10.1165/rcmb.2015-0265le

Cited by 2 publications

(1 citation statement)

References 6 publications

(11 reference statements)

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“…The influence of confounding conditions on the final diagnosis of endometriosis using this test was challenged. This is because multiple conditions, gynecological (for instance, adenomyosis [23][24][25][26], pelvic inflammatory disease (PID) [27][28][29], uterine fibroids [29][30][31] and ovarian cysts [29,32]) and non-gynecological (for instance, inflammatory bowel disease (IBD) [33] or rheumatoid arthritis [34][35][36], asthma [37], anxiety and depression [38][39][40]) could affect the levels of CA125 and BDNF.…”

Section: Introductionmentioning

confidence: 99%

Validation of an in vitro diagnostic test for endometriosis: impact of confounding medical conditions and lesion location

Daoud,

Archer,

Herranz-Blanco

2024

Preprint

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With the aim to shorten the time for diagnosis and accelerate access to correct management, a non-invasive diagnostic test for endometriosis was developed and validated. The IVD test combines an ELISA test kit to quantify CA125 and BDNF concentrations in serum and a data treatment algorithm hosted in medical software processing results from the ELISA test and responses to six clinical variables. Serum samples and clinical variables extracted from psychometric questionnaires from 77 patients were collected from the Oxford Endometriosis CaRe Centre biobank (UK). Case/control classification was performed based on laparoscopy and histological verification of the excised lesions. Biomarkers serum concentrations and clinical variables were introduced to the software, which generates the qualitative diagnostic result (positive or negative). This test allowed the detection of 32% of cases with superficial endometriosis, which is an added value given the limited efficacy of existing imaging techniques. Even in the presence of various confounding medical conditions, the test maintained a specificity of 100%, supporting its suitability for use in patients with underlying medical conditions.

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Section: Introductionmentioning

confidence: 99%

Validation of an in vitro diagnostic test for endometriosis: impact of confounding medical conditions and lesion location

Daoud,

Archer,

Herranz-Blanco

2024

Preprint

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Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function

Thompson

Britt

Pabelick

et al. 2017

Advances in Experimental Medicine and Biology

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Hypoxia is recognized as a contributor to pulmonary vascular diseases such as pulmonary hypertension. Hypoxia-induced inflammatory changes can enhance structural and functional changes in pulmonary artery (PA) in the context of PH. Accordingly, understanding how hypoxia and inflammation are linked in the context of pulmonary artery structure and function could be relevant towards development of novel therapies for PH. In this regard, factors such as thymic stromal lymphopoietin (TSLP), an inflammatory cytokine, and brain-derived neurotrophic factor (BDNF), a neurotrophin, have been found critical for nonvascular systems such as airway and asthma. While TSLP canonically affects the immune system, in nonvascular systems, noncanonical effects such as altered [Ca] and cell proliferation have been noted: aspects also relevant to the PA, where there is currently little to no data. Similarly, better known in the nervous system, there is increasing evidence that BDNF is locally produced by structural cells of the airway and can contribute to asthma pathophysiology. In this chapter, we summarize the potential relevance of factors such as TSLP and BDNF to the PA and in the context of hypoxia influences towards development of PH. We focus on cell sources and targets such as PA endothelial cells (PAECs) and smooth muscle cells (PASMCs), and the effects of TSLP or BDNF on intracellular Ca responses to vasoconstrictor agonist, cell proliferation, and potential signaling cascades involved.

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Secreted Brain-Derived Neurotrophic Factor and Asthma Severity

Cited by 2 publications

References 6 publications

Validation of an in vitro diagnostic test for endometriosis: impact of confounding medical conditions and lesion location

Validation of an in vitro diagnostic test for endometriosis: impact of confounding medical conditions and lesion location

Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function

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