This paper proposes an optimal control scheme based on a synchronized phasor (synchrophasor) for power system secondary voltage control. The framework covers voltage stability monitoring and control. Specifically, a voltage stability margin estimation algorithm is developed and built in the newly designed adaptive secondary voltage control (ASVC) method to achieve more reliable and efficient voltage regulation in power systems. This new approach is applied to improve voltage profile across the entire power grid by an optimized plan for VAR (reactive power) sources allocation; therefore, voltage stability margin of a power system can be increased to reduce the risk of voltage collapse. An extensive simulation study on the IEEE 30-bus test system is carried out to demonstrate the feasibility and effectiveness of the proposed scheme.