Secondary syphilis simulating oral hairy leukoplakia

Aquilina, C.; Viraben, R.; Denis, Philippe

doi:10.1067/s0190-9622(03)00484-5

Cited by 38 publications

(16 citation statements)

References 13 publications

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“…In 5 (26%) cases, the oral lesions were multiples (Compilato et al , ; Lu and Eng, ; Junkins‐Hopkins, ; Mani, ), while in the other 14 (74%) cases, the most frequent site of onset of the disease was the tongue (five cases, 37%) (Ikenberg et al , ; Bruce et al , ; Aquilina et al , ; Oztürk et al , ), followed by the labial (three cases, 21%) (Rajlawat et al , ; Lu and Eng, ; Mani, ), the buccal mucosa (two cases, 14%) (Ibrahim and Malu, ; Lu and Eng, ), the palate (three cases, 21%) (Murrell, ; Lu and Eng, ; Ban et al , ), and the gingiva (1 case, 7%) (Ficarra et al ,).…”

Section: Resultsmentioning

confidence: 99%

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

et al. 2013

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Section: Resultsmentioning

confidence: 99%

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

et al. 2013

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“…In lues maligna (ulcerative syphilis), patients may present with mucosal ulcerations . Furthermore, secondary syphilis involving oral mucosa may manifest, albeit rarely, in a white, adherent plaque on the tongue that mimics oral hairy leukoplakia …”

Section: Typical Manifestations Of Secondary Syphilismentioning

confidence: 99%

The great imitator revisited: the spectrum of atypical cutaneous manifestations of secondary syphilis

et al. 2014

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Syphilis is a well-known sexually transmitted infection infamous for its protean cutaneous manifestations. Over the last decade, the rate of infection in the USA has risen, particularly among human immunodeficiency virus (HIV)-infected individuals and certain ethnic groups. Although the primary chancre developing at the site of inoculation usually has typical and well-characterized features, cutaneous manifestations of secondary syphilis span a wide spectrum and mimic those of other dermatoses. This may be particularly evident in patients with HIV. Such deviations from the expected typical papulosquamous eruption may present a diagnostic challenge and delay diagnosis and therapy. Given the increasing incidence of syphilis among the immunosuppressed patient population, recognition of atypical cutaneous manifestations is critical for adequate management. We review a range of cutaneous manifestations of secondary syphilis and the skin diseases it may mimic.

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“…Differently, Hamlyn et al [9] reported a case series of three patients in whom secondary syphilis presented solely as a tonsillitis. A comprehensive review of the literature shows that oral lesions have been described as solitary or multiple ulcerations [7, 14, 18, 23, 32, 33], as erosions [10, 14], as a bullous-erosive lesion resembling pemphigus vulgaris [34], as macular, papular, and nodular lesions [3, 14, 18], as condylomata lata [6], as leukoplakia-like [35, 36], as oral hairy leukoplakia-like [8, 18] lesions, and as painless nodules on the tongue [37]. …”

Section: Discussionmentioning

confidence: 99%

Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review

Eyer-Silva

Freire²,

Horta-Araujo³

et al. 2017

Case Reports in Medicine

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Syphilis has been coined “the great imitator” due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchée. A painful split papule (fausse perlèche or false angular cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.

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Secondary syphilis simulating oral hairy leukoplakia

Cited by 38 publications

References 13 publications

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

The great imitator revisited: the spectrum of atypical cutaneous manifestations of secondary syphilis

Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review

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