Secondary S100B Protein Increase Following Brain Arteriovenous Malformation Rupture is Associated with Cerebral Infarction

Garzelli, Lorenzo; Jacquens, Alice; Amouyal, Caroline; Premat, Kévin; Sourour, Nader; Cortese, Jonathan; Haffaf, Idriss; Mathon, Bertrand; Lenck, Stéphanie; Clarençon, Frédéric; Degos, Vincent; Shotar, Eimad

doi:10.3390/molecules25215177

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…In addition, the expression of S100B may regulate cardiac metabolic function in the remodeling of the post-infarcted diabetic heart (Mohammadzadeh et al 2013 ). Moreover, secondary infarction caused by the rupture of cerebral arteriovenous malformation can cause secondary elevation of serum S100B protein level (Garzelli et al 2020 ).…”

Section: S100 Proteins In Cardiovascular Diseasesmentioning

confidence: 99%

“…Ventricular remodeling after myocardial infarction (Tsoporis et al 2005b;Mohammadzadeh et al 2013) Cerebral infarction (Garzelli et al 2020) Atrial fibrillation (Zhang et al 2013;Scherschel et al 2019) Acute coronary syndrome (Cai et al 2011) Dilated cardiomyopathy (Mazzini et al 2007) Heart failure (Li et al 2011;Chen et al 2020) Myocardial infarction (Tsoporis et al 2010) Atherosclerosis (Wu et al 2019) Cerebral ischemia/reperfusion injury (Yuan et al 2019) Aortic aneurysm (Roberts et al 2021) Cardiac arrest (Deye et al 2020) contains the binding site of the target protein, exerting their biological effect by interacting with the target protein (Liu et al 2013). In addition to Ca 2+ , the functions of many S100 proteins can be regulated by binding zinc or copper ions (Weisz and Uversky 2020).…”

Section: S100bmentioning

confidence: 99%

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S100 proteins in cardiovascular diseases

Zhou

Zha

Yang

et al. 2023

Mol Med

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Cardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts. The expression of S100 proteins is cell- and tissue-specific; they are implicated in cardiovascular, neurodegenerative, and inflammatory diseases and cancer. This review article discusses the progress in the research on the role of S100 protein family members in cardiovascular diseases. Understanding the mechanisms by which these proteins exert their biological function may provide novel concepts for preventing, treating, and predicting cardiovascular diseases.

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Section: S100 Proteins In Cardiovascular Diseasesmentioning

confidence: 99%

Section: S100bmentioning

confidence: 99%

S100 proteins in cardiovascular diseases

Zhou

Zha

Yang

et al. 2023

Mol Med

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“…Angiogenesis-associated proteins, such as VEGF (vascular endothelial growth factor), 9 MMP (matrix metalloproteinase), 10 inflammatory cytokines, 11 S100B (S100 calcium binding protein B), 12 etc, are highly overexpressed in bAVM nidus (Figure 2). Weinsheimer et al 13 have reported dysregulated VEGF, MAPK (mitogen-activated protein kinases), Wnt (wingless-related integration site), and Notch signaling in abnormal blood vessels.…”

Section: Protein Biomarkers Of Bavmmentioning

confidence: 99%

Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?

Venugopal

Sumi

2022

Stroke

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Vascular malformations of the brain (VMB) comprise abnormal development of blood vessels. A small fraction of VMBs causes hemorrhages with neurological morbidity and risk of mortality in patients. Most often, they are symptomatically silent and are detected at advanced stages of disease progression. The most common forms of VMBs are arteriovenous and cavernous malformations in the brain. Radiopathological features of these diseases are complex with high phenotypic variability. Early detection of these malformations followed by preclusion of severe neurological deficits such as hemorrhage and stroke is crucial in the clinical management of patients with VMBs. The technological advances in high-throughput omics platforms have currently infused a zest in translational research in VMBs. Besides finding novel biomarkers and therapeutic targets, these studies have withal contributed significantly to the understanding of the etiopathogenesis of VMBs. Here we discuss the recent advances in predictive and prognostic biomarker research in sporadic and familial arteriovenous malformations as well as cerebral cavernous malformations. Furthermore, we analyze the clinical applicability of protein and noncoding RNA-based molecular-targeted therapies which may have a potentially key role in disease management.

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Correlation analysis between the amniotic fluid contamination and clinical grading of neonatal hypoxic–ischemic encephalopathy and biomarkers of brain damage

Lv,

Liu,

Wang

et al. 2024

BMC Pediatr

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Background Amniotic fluid contamination (AFC) is a risk factor for neonatal hypoxic ischemic encephalopathy (HIE); however, the correlation between AFC level and the incidence and clinical grading of HIE, in addition to relevant biomarkers of brain damage, have not been assessed. Methods This single-center observational study included 75 neonates with moderate-to-severe HIE. The neonates with HIE were divided into four subgroups according to the AFC level: normal amniotic fluid with HIE group (NAF-HIE), I°AFC with HIE group (I°AFC-HIE), II°AFC with HIE group (II°AFC-HIE), and III°AFC with HIE group (III°AFC-HIE). The control groups consisted of 35 healthy neonates. The clinical grading of neonatal HIE was performed according to the criteria of Sarnat and Sarnat. Serum tau protein and S100B were detected by enzyme-linked immunosorbent assay kits. Correlations of serum tau protein and S100B were evaluated using the Pearson correlation analysis. Results (1) The incidence of neonatal HIE in the NAF-HIE group was 20 cases (26. 7%), I°AFC-HIE was 13 cases (17.3%), II°AFC-HIE was 10 cases (13.3%), and III°AFC-HIE was 32 cases (42. 7%). The incidence of moderate-to-severe HIE in the I°–III°AFC-HIE groups was 73.3% (55/75). (2) In 44 cases with severe HIE, 26 cases (59.1%) occurred in the III°AFC-HIE group, which had a significantly higher incidence of severe HIE than moderate HIE (p < 0.05). In NAF-HIE and I°AFC-HIE groups, the incidence of moderate HIE was 45.2% and 29.0%, respectively, which was higher than that of severe HIE (X2 = 9.2425, p < 0.05; X2 = 5.0472, p < 0.05, respectively). (3) Serum tau protein and S100B levels in the HIE groups were significantly higher than in the control group (all p < 0.05), and were significantly higher in the III°AFC-HIE group than in the NAF-HIE and I°AFC-HIE groups (all p < 0.05). (4) Serum tau protein and S100B levels in the severe HIE group were significantly higher in the moderate HIE group (all p < 0.05). (5) Serum tau protein and S100B levels were significantly positively correlated (r = 0.7703, p < 0.0001). Conclusion Among children with severe HIE, the incidence of III°AFC was higher, and the levels of serum tau protein and S100B were increased. AFC level might be associated with HIE grading.

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Secondary S100B Protein Increase Following Brain Arteriovenous Malformation Rupture is Associated with Cerebral Infarction

Cited by 3 publications

References 16 publications

S100 proteins in cardiovascular diseases

S100 proteins in cardiovascular diseases

Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?

Correlation analysis between the amniotic fluid contamination and clinical grading of neonatal hypoxic–ischemic encephalopathy and biomarkers of brain damage

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