Secondary renal tubular dysgenesis in a newborn exposed to angiotensin Ⅱ receptor antagonist during gestation

Gang, Mi Hyeon; Lee, Yong Wook; Chang, Meayoung

doi:10.3345/cep.2020.00752

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Selective blockage of AT1 receptors during second half of pregnancy is therefore associated with severe tubular dysgenesis and renal impairment (Table 2 ). 5 , 9 , 10 , 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

“…2). 5,[9][10][11][12][13] Accordingly, in our newborn, although fetal exposure to AT1 blockers occurred from the first trimester, the early detection and immediate discontinuation of the drug at the beginning of the third trimester resulted in a normal glomerular function, and a mild proximal tubular dysfunction. However, the possible alteration of nephron-vascular architecture as documented in fetus exposure to AT1 blockers, 8 can result in an inappropriate activation of the intrarenal RAAS contributing to the pathogenesis of hypertension and renal damage.…”

Section: Case Reportmentioning

confidence: 99%

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Sustained activation of the renin–angiotensin–aldosteron system after fetal exposure to AT1 blockers: Effects on kidney and bone in a preterm newborn

Damato¹,

Rembouskos²,

Cafagna³

et al. 2022

J of Obstet and Gynaecol

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The renin-angiotensin-aldosterone system (RAAS) plays a key role in development of fetal kidney. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor type 1 (AT1) antagonists alter RAAS-signaling compromising metanephrogenesis, and vascular and tubular development. The result is a fetal "RAS blockage syndrome" that may occur not only following exposure during the second and third trimester, but also after the use of these drugs at the beginning of pregnancy. The in-utero exposure to AT1 antagonists is not confined exclusively to the risk of neonatal renal failure, but also to skull ossification defect that worsens the neonatal prognosis. We report the case of early arterial hypertension development, marked increase of plasma renin and aldosterone, severe hypocalvaria, and low bone mineralization in a female preterm infant in-utero exposed to AT1 antagonists.

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“…Selective blockage of AT1 receptors during second half of pregnancy is therefore associated with severe tubular dysgenesis and renal impairment (Table 2 ). 5 , 9 , 10 , 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Sustained activation of the renin–angiotensin–aldosteron system after fetal exposure to AT1 blockers: Effects on kidney and bone in a preterm newborn

Damato¹,

Rembouskos²,

Cafagna³

et al. 2022

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…while 10% have a particularly poor prognosis (e.g., end-stage renal disease and death). 7) In this issue of Clin Exp Pediatr, Gang et al 8) report a case of neonatal RTD due to ANG II receptor blocker exposure in utero during the entire pregnancy. The patient died soon after birth of refractory hypotension and renal failure.…”

mentioning

confidence: 99%

“…In this issue of Clinical and Experimental Pediatrics , Gang et al [ 8 ] report a case of neonatal RTD due to ANG II receptor blocker exposure in utero during the entire pregnancy. The patient died soon after birth of refractory hypotension and renal failure.…”

mentioning

confidence: 99%