Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles

Ruciński, Antoni; Traini, G.; Roldan, A. Baratto; Battistoni, G.; Simoni, Micol De; Dong, Yunsheng; Fischetti, M.; Frallicciardi, P.M.; Gioscio, E.; Mancini‐Terracciano, C.; Marafini, M.; Mattei, I.; Mirabelli, R.; Muraro, S.; Sarti, A.; Schiavi, A.; Sciubba, A.; Camillocci, E. Solfaroli; Valle, S.M.; Patera, V.

doi:10.1016/j.ejmp.2019.06.001

Cited by 6 publications

(7 citation statements)

References 47 publications

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“…Significant production of β + was also reported for 4 He ion on PMMA target [43]. Secondary proton fluence from 300 MeV/u 16 O induced reaction on PMMA target was measured to be (74.18 ± 0.40±13.02)x10 −3 sr −1 at 60 o and was ∼6.5 times lower at 90 o [14]. At 210 MeV/u 16 O beam energy, these values were ∼3.3-3.6 times lower.…”

Section: Experimental Studiesmentioning

confidence: 80%

“…However, this pattern drastically changed near and beyond the distal end of the Bragg peak. Here, 11,12 C, 16 O, and 13,14,15 N had almost comparable LET [62]. Experimentally measured LET distribution of SCPs, for 380 MeV/u 12 C beam, was compared with the GEANT simulation [64,65].…”

Section: Simulation Studiesmentioning

confidence: 96%

“…4 He ions might turn out to be a good choice, as projectile fragmentation and neutron production are expected to be lower than in the case of 12 C beams while having good localization of the energy deposition [12,13]. For 16 O, fragmentation is higher and in vitro studies had also provided a slightly larger RBE value [14,15] compared to 12 C, but carbon beam has a higher impact on cell survival. However, in all the cases, actual volume which is exposed to primary and secondary radiation strongly depends on patient positioning and on anatomical variation of the target organ during treatment [5,6].…”

Section: Secondary Radiation In Ion Beam Therapymentioning

confidence: 99%

“…Besides proton and carbon, performance of ions like 4 He, 16 O, and 20 Ne in heavy ion therapy was investigated in several works [14,15,[41][42][43][44][45][46][47][48][49]. The total number of secondary protons produced by 220 MeV 12 C beam in PMMA target at 90 o was (4.49 ± 0.13±0.59)x10 −3 sr −1 which was ∼4.5 times that produced by 125 MeV 4 He (having the same range as 220 MeV 12 C in PMMA) [41,42]. Production of 2 H and 3 H was ∼5%-10% and ∼1%-2%, respectively, of the total production of 1 H+ 2 H+ 3 H. For 125 MeV/u 4 He projectile, the energy of the emitted 1 H extended beyond 240 MeV at 5 o [42].…”

Section: Experimental Studiesmentioning

confidence: 99%

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Secondary Radiation in Ion Therapy and Theranostics: A Review

Nandy

2021

Front. Phys.

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Ion therapy has emerged as one of the preferred treatment procedures in some selective indication of cancer. The actual dose delivered to the target volume may differ from the planned dose due to wrong positioning of the patient and organ movement during beam delivery. On the other hand, some healthy tissues outside the planned volume may be exposed to radiation dose. It is necessary to determine the primary particle range and the actual exposed volume during irradiation. Many proposed techniques use secondary radiation for the purpose. The secondary radiation consists mainly of neutrons, charged fragments, annihilation photons, among others, and prompt gammas. These are produced through nuclear interaction of the primary beam with the beam line and the patient’s body tissue. Besides its usefulness in characterizing the primary beam, the secondary radiation contributes to the risk of exposure of different tissues. Secondary radiation has significant contribution in theranostics, a comparatively new branch of medicine, which combines diagnosis and therapy. Many authors have made detailed study of the dose delivered to the patient by the secondary radiation and its effects. They have also studied the correlation of secondary charged particles with the beam range and the delivered dose. While these studies have been carried out in great detail in the case of proton and carbon therapy, there are fewer analyses for theranostics. In the present review, a brief account of the studies carried out so far on secondary radiation in ion therapy, its effect, and the role of nuclear reactions is given.

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Section: Experimental Studiesmentioning

confidence: 80%

Section: Simulation Studiesmentioning

confidence: 96%

Section: Secondary Radiation In Ion Beam Therapymentioning

confidence: 99%

Section: Experimental Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Secondary Radiation in Ion Therapy and Theranostics: A Review

Nandy

2021

Front. Phys.

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“…Such measurements were part of a complex experiment, exploited with a multi-purpose detector setup, aiming for the characterization of the interactions of different ion species of several energies with the purpose of studying the secondary particle emission trough the measurement of prompt photons, charged and β + -emitter fragments. More details can be found in (Mattei et al 2016, Rucinski et al 2016, Toppi et al 2016.…”

Section: Methodsmentioning

confidence: 99%

Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by⁴He ion beams in a PMMA target

et al. 2017

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Abstract.Nowadays there is a growing interest in Particle Therapy treatments exploiting light ion beams against tumors due to their enhanced Relative Biological Effectiveness and high space selectivity. In particular promising results are obtained by the use of 4 He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Ion-Beam Therapy center are reported. For the first time the absolute fluxes and the energy spectra of the fragments -protons, deuterons, and tritons -produced by 4 He ion beams of 102, 125 and 145 MeV/u energies on a poly-methyl methacrylate target were evaluated at different angles. The obtained results are particularly relevant in view of the necessary optimization and review of the Treatment Planning Software being developed for clinical use of 4 He beams in clinical routine and the relative benchmarking of Monte Carlo algorithm predictions.

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Detecting perturbations of a radiation field inside a head‐sized phantom exposed to therapeutic carbon‐ion beams through charged‐fragment tracking

et al. 2022

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Purpose Noninvasive methods to monitor carbon‐ion beams in patients are desired to fully exploit the advantages of carbon‐ion radiotherapy. Prompt secondary ions produced in nuclear fragmentations of carbon ions are of particular interest for monitoring purposes as they can escape the patient and thus be detected and tracked to measure the radiation field in the irradiated object. This study aims to evaluate the performance of secondary‐ion tracking to detect, visualize, and localize an internal air cavity used to mimic inter‐fractional changes in the patient anatomy at different depths along the beam axis. Methods In this work, a homogeneous head phantom was irradiated with a realistic carbon‐ion treatment plan with a typical prescribed fraction dose of 3 Gy(RBE). Secondary ions were detected by a mini‐tracker with an active area of 2 cm2, based on the Timepix3 semiconductor pixel detector technology. The mini‐tracker was placed 120 mm behind the center of the target at an angle of 30 degrees with respect to the beam axis. To assess the performance of the developed method, a 2‐mm thick air cavity was inserted in the head phantom at several depths: in front of as well as at the entrance, in the middle, and at the distal end of the target volume. Different reconstruction methods of secondary‐ion emission profile were studied using the FLUKA Monte Carlo simulation package. The perturbations in the emission profiles caused by the air cavity were analyzed to detect the presence of the air cavity and localize its position. Results The perturbations in the radiation field mimicked by the 2‐mm thick cavity were found to be significant. A detection significance of at least three standard deviations in terms of spatial distribution of the measured tracks was found for all investigated cavity depths, while the highest significance (six standard deviations) was obtained when the cavity was located upstream of the tumor. For a tracker with an eight‐fold sensitive area, the detection significance rose to at least nine standard deviations and up to 17 standard deviations, respectively. The cavity could be detected at all depths and its position measured within 6.5 ± 1.4 mm, which is sufficient for the targeted clinical performance of 10 mm. Conclusion The presented systematic study concerning the detection and localization of small inter‐fractional structure changes in a realistic clinical setting demonstrates that secondary ions carry a large amount of information on the internal structure of the irradiated object and are thus attractive to be further studied for noninvasive monitoring of carbon‐ion treatments.

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Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles

Cited by 6 publications

References 47 publications

Secondary Radiation in Ion Therapy and Theranostics: A Review

Secondary Radiation in Ion Therapy and Theranostics: A Review

Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by⁴He ion beams in a PMMA target

Detecting perturbations of a radiation field inside a head‐sized phantom exposed to therapeutic carbon‐ion beams through charged‐fragment tracking

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Secondary radiation measurements for particle therapy applications: Charged secondaries produced by 16O ion beams in a PMMA target at large angles

Cited by 6 publications

References 47 publications

Secondary Radiation in Ion Therapy and Theranostics: A Review

Secondary Radiation in Ion Therapy and Theranostics: A Review

Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by4He ion beams in a PMMA target

Detecting perturbations of a radiation field inside a head‐sized phantom exposed to therapeutic carbon‐ion beams through charged‐fragment tracking

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Secondary radiation measurements for particle therapy applications: nuclear fragmentation produced by⁴He ion beams in a PMMA target