Secondary Preventive Effects of a Calcium Antagonist for Ischemic Heart Attack - Randomized Parallel Comparison With .BETA.-Blockers -

Calcium Channel Antagonists Prevent Cardiovascular Events in Japanese Patients With Myocardial Infarction Even in the Absence of Coronary Artery Spasm

“…12 Their results are consistent with those of the JBCMI study, but in contrast to the JBCMI study, they excluded patients with coronary artery spasm. Their data showed that VSA patients prior to exclusion represented approximately 41% of the recruited AMI patients.…”

Impact of left ventricular ejection function on blood pressure-lowering therapy in hypertensive patients with coronary artery disease

“…b blocker and ACE-I were more frequently administered in patients with reduced LVEF, while CCB was more frequently prescribed in patients with preserved LVEF. Many aggregate reports show evidence that b blocker and ACE-I decrease cardiovascular events in prior myocardial infarction patients with reduced LVEF [31,32], and improved prognosis in heart failure patients with reduced LVEF [33][34][35][36][37]. In the present study, the frequency of hospitalization because of heart failure among MACE in patients with reduced LVEF was higher than those with preserved LVEF.…”

Effects of αβ-Blocker Versus β1-Blocker Treatment on Heart Rate Response During Incremental Cardiopulmonary Exercise in Japanese Male Patients with Subacute Myocardial Infarction

“…A previous study reported that Japanese MI patients were treated with a mean carvedilol dose of 3.48 ± 1.61 mg/day before hospital discharge and 7.71 ± 4.58 mg/day at 12 months after MI onset, or a mean bisoprolol dose of 1.26 ± 0.57 mg/day before hospital discharge and 2.47 ± 1.20 mg/day at 12 months after MI onset [11]. Another study in Japan reported that atenolol was started at a low dose and titrated up to the target dose of 25–50 mg/day at one month after MI onset [27]. In the present study population (i.e., MI patients at one month after MI onset), although the mean doses of carvedilol and atenolol were considered clinically appropriate, the mean dose of bisoprolol was slightly higher than that noted in previous study populations.…”