Secondary polycythaemia in chronic respiratory insufficiency.

Vanuxem, D.; Guillot, Caroline; Fornaris, E.; Weiller, Pierre Jean; Grimaud, C

doi:10.1136/thx.32.3.317

Cited by 14 publications

(10 citation statements)

References 14 publications

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“…La consé quence est une gêne à l'oxygénation tissu laire pouvant contribuer au développe ment de polyglobulies réactionnelles chez l'insuffisant respiratoire hypoxémique [17], mais aussi, chez le sujet normal grand fumeur [6,14,15,23].…”

Section: Discussionunclassified

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Tabagisme et carboxyhémoglobine chez les donneurs de sang

et al. 1983

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The authors studied the tobacco consumption of 283 blood donors and its consequences. 151 were nonsmokers and 132 were smokers (47.7% smoke more than 10 g/day). Their mean HbCO level was 4.3 ± 0.2% (highest level 15%). HbCO levels are significantly correlated with daily tobacco consumption (p < 0.001) and can be estimated with the following regression equation: HbCO% = 0.176 (tobacco in grams/day) + 1.967. For a similar consumption, inhalers exhibit significantly (p < 0.001) higher HbCO levels than noninhalers and the increase is significantly higher (p < 0.02) in inhalers who smoked 1 h or less prior to blood sampling. High HbCO levels have two consequences: in the donors they have caused a tobacco polycythemia syndrome and in the recipients they have caused acute problems in cases of massive blood transfusion and cardiovascular surgery with extracorporeal circulation

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Section: Discussionunclassified

“…L'effet nocif sur le transport de l'oxygè ne, d'un taux élevé de carboxyhémoglobi ne (HbCO) lié au tabagisme est bien connu [6,14,15,17,23). Dans une étude récente [19] nous avons discuté les résul tats des mesures d'HbCO en fonction des habitudes tabagiques des malades exami nés au Laboratoire d'Explorations Fonc tionnelles Respiratoires.…”

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Tabagisme et carboxyhémoglobine chez les donneurs de sang

et al. 1983

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“…The applicant claimed proprietary rights for studies performed on behalf of the applicant and/or using the applicant's product (Bendahan et al, 1997(Bendahan et al, , 2001(Bendahan et al, , 2002Briand et al, 1986Briand et al, , 1992Creff, 1982;Dauverchain, 1982;Fornaris et al, 1984;Giannesini et al, 2009;Goubel et al, 1995aGoubel et al, , 1995bGoubel et al, , 1997Moinard et al, 2008;Thuillier-Brustion et al, 1990Vanuxem et al, 1986Vanuxem et al, , 1990Verleye et al, 1995) and for information pertaining to the production process of citrulline-malate. For a number of studies the applicant requested confidentiality (Colin, 1972;Commandré, 1973;Creff, 1972;Mande, 1978;Taillade, 1984;Vallat, 1972).…”

Section: Information Provided By the Applicantmentioning

confidence: 99%

“…The provided reviews (Curis et al, 2005;Gibala et al, 1997;Rabier and Kamoun, 1995;Vanuxem et al, 1986) contained no primary data which could be used for the scientific substantiation of the claim.…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to citrulline malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Publication¹

2012

EFSA Journal

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European Food Safety Authority (EFSA), Parma, Italy ABSTRACTFollowing an application from Biocodex, submitted pursuant to Article 13(5) of Regulation (EC) No 1924No /2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to citrulline-malate and faster recovery from muscle fatigue after exercise. Citrulline-malate is sufficiently characterised. The claimed effect is "maintenance of ATP levels through reduction of lactates in excess for an improved recovery from muscle fatigue". The target population proposed by the applicant is healthy children above six years of age and adults. The Panel considers that faster recovery from muscle fatigue after exercise contributing to the restoration of muscle function is a beneficial physiological effect. A total of 33 references were considered as pertinent to the claim by the applicant. A number of studies were provided with hospitalised patients or outpatients who presented with various forms of asthenia or fatigue. No conclusions could be drawn from these studies for the scientific substantiation of the claim. No conclusions could be drawn from one study carried out in athletes, owing to the methodological limitations of the study. A number of mechanistic, animal and in vitro studies were submitted. In the absence of evidence for an effect of consumption of citrulline-malate on a faster recovery from muscle fatigue after exercise in humans, these studies cannot be used as a source of data for the scientific substantiation of the claim as their results cannot predict the occurrence of an effect of citrulline-malate on recovery from muscle fatigue after exercise in vivo in humans. The Panel concludes that a cause and effect relationship has not been established between the consumption of citrulline-malate and faster recovery from muscle fatigue after exercise. © European Food Safety Authority, 2012 KEY WORDSCitrulline-malate, muscle fatigue, exercise, health claims The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence and including a request for the protection of proprietary data.The food constituent that is the subject of the health claim is citrulline-malate, which is a mixture of L-citrulline and D,L-malic acid (1:1) forming a salt. The Panel considers that citrulline-malate is sufficiently characterised.The claimed effect is "maintenance of ATP levels through reduction of lactates in excess for an improved recovery from muscle fatigue". The target population proposed by the applicant is healthy children above six years of age and adults. The Panel considers that faster recovery from muscle fatigue after exercise contributing to the restoration of muscle function is a beneficial physiological effect.A total of 33 references were considered as pertinent to the claim by the applicant. These references comprised 18 human studies, four animal studies, seven in vitro studies, and f...

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“…La conséquence de cette double action est une entrave à l'oxygénation tissu laire, pouvant contribuer au développement de polyglobulies réactionnelles chez l'insuf fisant respiratoire fumeur [27], mais égale ment chez le sujet normal gros fumeur [8,21,23,32].…”

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Tabagisme et monoxyde de carbone

Vanuxem¹,

Guillot²,

Grimaud³

1980

Respiration

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Among 2,069 patients subjected to pulmonary function tests, 20% were smokers with a mean oxyhemoglobin (HbCO) level of 5.2%. Similar values for HbCO (2.4%) were found in non-smokers and ex-smokers. A positive correlation was observed between daily tobacco consumption and HbCO level, i.e. HbCO = 0.123 (g/day) + 3.433. For a similar consumption (16 g/day), smokers who inhaled the smoke had a significantly higher level of HbCO than smokers who did not (5.8 vs. 4.7%). The interval separating the time when the last cigarette was smoked from HbCO measurement is of utmost importance: for a similar tobacco consumption (10 g/day) HbCO ranged from 6.5 ± 0.5% when the interval was 1 h to 4.6 ± 0 > .3% when it was 3 h (p < 0.005). In some cases, there were discrepancies between the number of cigarettes smoked as indicated by the subjects and the measured levels of HbCO. Possible inhalation of exogenous CO from other sources than smoking or increased production of endogenous CO could account for these differences.

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Secondary polycythaemia in chronic respiratory insufficiency.

Cited by 14 publications

References 14 publications

Tabagisme et carboxyhémoglobine chez les donneurs de sang

Tabagisme et carboxyhémoglobine chez les donneurs de sang

Scientific Opinion on the substantiation of a health claim related to citrulline malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Tabagisme et monoxyde de carbone

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