Secondary Organizing Pneumonia Mimicking Pulmonary Metastasis of a Diffuse Large Cell Lymphoma

Lacerda, Catarina; Lages, Joana; Rolo, Rui

doi:10.1016/j.arbr.2017.10.030

Cited by 1 publication

(2 citation statements)

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“…Our current case is the first reported case of OP associated with EATL. Our review of the literature revealed only 10 English language reports of OP associated with lymphoma that specify the absence of prior anticancer treatment (Table 1) [4,6–14]. There did not appear to be a clear predilection for aggressive or indolent lymphoma subtypes, although nine out of 10 prior reports described cases of B‐cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…In seven patients, OP and lymphoma were diagnosed on the same biopsy specimen, with OP seemingly a direct reaction to lymphomatous infiltration of the lung [7–11,13,14]. In three of the four remaining cases (including our case), diagnosis of OP was made by TBB or TTB, making it difficult to exclude concurrent pulmonary lymphoma due to sampling error [6,12]. Indeed, of the six patients who were initially diagnosed with OP via TBB or TTB, three also underwent a surgical lung biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Organizing pneumonia associated with T‐cell lymphoma

Chan

Fagarasanu

Reid

et al. 2020

Respirology Case Reports

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A 61‐year‐old male with a history of coeliac disease was diagnosed with organizing pneumonia (OP) on transbronchial and transthoracic lung biopsies. He then developed refractory coeliac disease type II and haemophagocytic lymphohistiocytosis. Nine months after his initial diagnosis of OP and after multiple biopsies of the lung, duodenum, and bone marrow, he was diagnosed with enteropathy‐associated T‐cell lymphoma (EATL). Although OP in patients with lymphoma is most commonly attributed to chemotherapeutic agents or bone marrow transplant, it may be seen in the absence of prior anticancer treatment. The mechanism linking OP and lymphoma is unclear but OP could represent a syndrome of T‐cell dysfunction or develop as a direct reaction to malignant infiltration of the lung. In patients with atypical presentations, exclusion of an alternate diagnosis must be pursued using surgical lung biopsy, wherever possible. This is the first reported case of OP associated with EATL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%