Secondary metabolites profiles and antioxidant activities of germinated brown and red rice

Nurnaistia, Yugianti; Aisyah, Siti; Munawaroh, Heli Siti Halimatul; Zackiyah,

doi:10.1088/1742-6596/1013/1/012204

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Thus high consumption of pigmented and unpolished rice does not cause the occurrence of type-II diabetes. 7 Being antioxidants these compounds prevent other degenerative diseases, such as chronic inflammation, cardiovascular diseases, atherosclerosis, Alzheimer's disease, cancer of colon, liver, prostate, breast, and so forth. 8 During the germination of rice seeds the endogenous hydrolytic enzymes get overtly activated and it breaks down the complex polysaccharide and protein molecules into simpler oligosaccharides and amino acids.…”

Section: Introductionmentioning

confidence: 99%

“…These bioactive compounds act as antioxidants and thus have hypoglycemic effect on human health. Thus high consumption of pigmented and unpolished rice does not cause the occurrence of type‐II diabetes 7 . Being antioxidants these compounds prevent other degenerative diseases, such as chronic inflammation, cardiovascular diseases, atherosclerosis, Alzheimer's disease, cancer of colon, liver, prostate, breast, and so forth 8 …”

Section: Introductionmentioning

confidence: 99%

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The molecular and metabolic events behind different germination stages of rice seeds: A metabolomics perspective

Hazra,

Das

2024

JSFA Reports

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Seed germination is a crucial stage for the completion of plants' life cycle. The process of seed germination is a very important phenomenon for agricultural food and crop production and to understand the underlying food chemistry. Rice (Oryza sativa L.) being easy to grow and cheap source of phytonutrients is a fundamental food crop across the world. Several researches are going on for years to improve the production of rice, ameliorate the deadly bacterial or fungal diseases utilizing genetics, transcriptomics and proteomics aspects. Metabolomics is a very new arena of research in this field. With the help of modern day metabolomic tools and technologies, researchers are incessantly trying to unveil the metabolic construction of rice seeds and new to this topic is seed‐germination. The principal aim for this review on metabolomics of germinating rice seeds is to have a big picture on the key molecular, cellular and metabolic events of germination. This review tries to summarize all the available data to fulfill the aforesaid aim.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The molecular and metabolic events behind different germination stages of rice seeds: A metabolomics perspective

Hazra,

Das

2024

JSFA Reports

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“…these six compounds along with some other bioactive compounds were found to be present in black rice bran as major constituents [30][31][32][33]. Though the antioxidant activity of these compounds were studied by various researchers but their antidiabetic properties are yet to be established [34] , [35] , [25]. Therefore, the present work was designed to evaluate the antidiabetic activity of these compounds by assessing their a nity to bind with DPP-4 enzyme using Induced Fit Docking.…”

Section: Introductionmentioning

confidence: 99%

In silico Assessment of Dipeptidyl Peptidase 4 (DPP-4) Inhibiting Potential of a few Bioactive Compounds Present in Black Rice Bran for Effective Management of Postprandial Hyperglycemia

Bhuyan

Ganguly

2023

Preprint

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Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of prescription medicines that are used to control hyperglycemia in adults with type 2 diabetes. DPP-4 inhibitors lower blood sugar by helping the body increase the level of the hormone insulin after meals. In recent years many phenolic compounds, isolated from folk medicinal plants with anti- diabetic activity, are proved to show potent inhibitory effects against DPP- 4 enzyme. Black rice bran extract, which is rich in phenols, produces hyperglycemic effect on experimental animals. The present study was designed to evaluate molecular interactions existing between the major bioactive compounds present in black rice bran and DPP-4 enzyme. Molecular docking, binding energy calculation, evaluation of ADMET properties and Molecular Dynamics simulation for 50 nanoseconds were carried out to reveal the nature and stability of the enzyme-ligand complex formed due to such interactions. The results obtained indicate that out of the six bioactive compounds chosen, C3G (cyanidin 3-O-glucoside) and FLS (6´-O-feruloylsucrose) have the highest docking scores and they can produce stable complexes with DPP-4 which might lead to its inactivation. Therefore, it can be concluded that black rice bran extract may produce antidiabetic activity by inhibiting the DPP-4 enzyme. Moreover, the pharmacokinetic studies reveal that the compounds chosen are safe and produce no hepatotoxicity. This preliminary theoretical study can provide a strong base for further studies towards the development of lead molecules for new antidiabetic drugs with lower side effects.

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“…Though the antioxidant activity of these compounds were studied by various researchers but the exact mechanism of the antidiabetic effect shown by these phytochemicals is yet to be established. 16,24,25 To elucidate the mechanism of antidiabetic effect of BRBE, the present work was designed by combining in vitro and in silico studies. The percentage inhibition of alpha glucosidase enzyme was studied with fresh BRBE through in vitro experiment while molecular interactions existing between the major compounds in the rice bran extract with the enzyme was studied using in silico approaches.…”

Section: Introductionmentioning

confidence: 99%

Alpha glucosidase inhibitory properties of a few bioactive compounds isolated from black rice bran: combinedin vitroandin silicoevidence supporting the antidiabetic effect of black rice

et al. 2022

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Secondary metabolites profiles and antioxidant activities of germinated brown and red rice

Cited by 6 publications

References 9 publications

The molecular and metabolic events behind different germination stages of rice seeds: A metabolomics perspective

The molecular and metabolic events behind different germination stages of rice seeds: A metabolomics perspective

In silico Assessment of Dipeptidyl Peptidase 4 (DPP-4) Inhibiting Potential of a few Bioactive Compounds Present in Black Rice Bran for Effective Management of Postprandial Hyperglycemia

Alpha glucosidase inhibitory properties of a few bioactive compounds isolated from black rice bran: combinedin vitroandin silicoevidence supporting the antidiabetic effect of black rice

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