Secondary Metabolites of the Genus Trichilia: Contribution to the Chemistry of Meliaceae Family

Abstract

According to the literature data on the chemical composition of the Trichilia genus performed in this work, it can be concluded that 334 different compounds were isolated and identified, distributed in monoterpenes, sesquiterpenes, diterpenes, triterpenes, steroids, limonoids, coumarins, flavonoids, lignans, phenolic acids, amino acids and lactones. Together with the structures of this compound, data from botanical classification and pharmacological results from extracts and pure compounds on the Trichilia genus were also described. The compounds derived from terpenes pathway were more significant, corresponding to about 87.7% of isolated and identified compounds from various Trichilia species. Among the different terpenoid skeletons of this kind, limonoids were meanly reported, appearing a total of 33.9% of compounds isolated from several Trichilia species.

Trichilones A–E: New Limonoids from Trichilia adolfi

“…The Meliaceae family of plants includes species dispersed in tropical areas of America, Africa and Asia [1,2]. The Trichilia genus, part of this family, comprises several species that have been studied as they are used in traditional medicine, and phytochemical investigations have revealed that limonoids are typical constituents.…”

“…Bark, leaves, fruits and roots have been used to treat a broad variety of disorders, including stomach, diarrhea, dermatitis, taeniasis, pneumonia, lung, kidney and liver pains, as well to heal wounds [11]. The biological and pharmacological properties of Trichilia species have been reviewed by Longhini et al [1], Garg [12], Curcino Vieira et al [2] and Komane et al [13]. More limonoids have been studied for their effects on inflammatory disorders [14,15] and as cytotoxic agents [9,16,17].…”

Curcinomarcoide, a Novel Limonoid From Trichilia hirta (Meliaceae)—Complete 1H and 13C Chemical Shift Assignments

“…A phytochemical revision of the Trichilia genus 3 showed that 334 different terpenoids representing 87.7% of the compounds were isolated and identified from various species of Trichilia .…”

Triconoids A–D, Four Limonoids Possess Two Rearranged Carbon Skeletons from Trichilia connaroides

“…Trichilia species of the Meliaceae family are well-known for metabolizing structurally diverse limonoids with a broad spectrum of biological activities . The plants of T.…”