Secondary metabolites of a soft coral (Nephthea sp.) of the Bay of Bengal

Patra, Anirban; Majumdar, Anadi

doi:10.3998/ark.5550190.0004.916

Cited by 8 publications

(9 citation statements)

References 18 publications

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“…362 The absolute stereochemistry of the N-palmitate 417, isolated from a Bay of Bengal collection of Nephthea sp., was deduced by analysis of 1 H-1 H coupling constants of the acetonide derivative and comparison of optical properties with known compounds. 363 Acylspermidines 418-420, isolated from an Okinawan collection of Sinularia sp. soft coral, 364 were all potently cytotoxic towards A431 cells.…”

Section: Coelenteratesmentioning

confidence: 99%

Marine natural products

et al. 2005

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This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (656 for 2003), together with their relevant biological activities, source organisms and country or origin. Biosynthetic studies or syntheses that lead to the revision of structures or stereochemistries have been included (78), including any first total syntheses of a marine natural product.

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Section: Coelenteratesmentioning

confidence: 99%

Marine natural products

et al. 2005

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“…Furthermore, the metabolic pool of soft corals belonging to the genus Nephthea has also been shown to comprise a limited number of nitrogenous metabolites including ceramides, such as 2-N-nonanoyl-4,5-dihydrosphingosine (12) (Abdelhafez et al, 2019;Hu et al, 2011), which was formerly reported from Nephthea sp. (Patra and Majumdar, 2003).…”

Section: Resultsmentioning

confidence: 99%

Natural metabolites from the soft coralNephtheasp. as potential SARS-CoV-2 main protease inhibitors

Abdelhafez

Fahim

Mustafa

et al. 2021

Natural Product Research

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The ongoing spread of SARS-CoV-2 has created a growing need to develop effective antiviral treatments; therefore, this work was undertaken to delve into the natural metabolites of the Red Sea soft coral Nephthea sp. (family Nephtheidae) as a source of potential anti-COVID-19 agents. Overall, a total of 14 structurally diverse minor constituents were isolated and identified from the petroleum ether fraction of Nephthea sp. The characterized compounds were screened and compared for their inhibitory potential against SARS-CoV-2 main protease (M pro ) using Autodock Vina and MOE software.Interestingly, most compounds were able to bind effectively to the active site of M pro , of which nephthoside monoacetate (1); an acylated tetraprenyltoluquinol glycoside, exhibited the highest binding capacity in both software with comparable interaction energies to the ligand N3 and moderately acceptable drug-likeness properties, which drew attention to the relevance of marine-derived metabolites from Nephthea sp., particularly compound (1), to develop potential SARS-CoV-2 protease inhibitors.

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“…Elshamyet al [38] reported that soft coral are distinguished by a subset of diterpenoids known as cespitularia, cespihypotin, cespitulactam, cespitularin, and cespitulons. The isolated cespitularinditerpenoids and secosteroids from marine exhibited cytotoxic activity.These compounds' antiviral activities were assessed by comparing them to the positive control, cyclosporine A [39]. The steroid Chabrolosteroid B and the oxygenated sterol Nebrosteroid O were previously obtained and formerly characterized by Nephtheachabrolii [30,31].…”

Section: Metabolic Profilingmentioning

confidence: 99%

Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

Hassan

elhawary

Emam³

et al. 2022

Egypt. J. Chem.

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The most catastrophic problem that affects living standards is viral infections. This work aims to discover and evaluate new antiviral agents from marine sources. Antiviral activities of n-hexane, dichloromethane, ethyl acetate, and butanol fractions of octocoralNephtheasp. were examined in vitro against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses using MTT assay. n-hexane fraction was the most bioactive fraction with IC50 30.23 ± 0.007g/ml on both viruses. The metabolic profiling of the n-hexane fraction was investigated as the most potent fraction via the Ultra Performance Liquid Chromatography method joined to a quadrupole time-of-flight hybrid mass spectrometer (UPLC-Q/TOF-MS), which led to the identification of twelve secondary metabolites (diterpenoid, triterpene, steroids, and fatty acids). A molecular docking investigation was supported by using Molecular Operating Environment (MOE) software to prove the mechanism of action. The highest binding energy score was for lauric acid with -10.2157 kcal/mol toward the Thymidine Kinase (TK), and Chabrolohydroxybenzoquinone G toward 3C protease (3Cpro) enzyme with -16.5115 kcal/mol. Finally, the results were confirmed by the inhibitory effect of bioactive fraction in-vitro against TK and 3Cpro enzymes. Our results highlighted Nephtheasp. as a rich source of non-polar effective constituents that might be a promising candidate for controlling viral infections.

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Secondary metabolites of a soft coral (Nephthea sp.) of the Bay of Bengal

Cited by 8 publications

References 18 publications

Marine natural products

Marine natural products

Natural metabolites from the soft coralNephtheasp. as potential SARS-CoV-2 main protease inhibitors

Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

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