Secondary Metabolites, Glandular Trichomes and Biological Activity of <i>Sideritis montana</i> L. subsp. <i>montana</i> from Central Italy

Venditti, Alessandro; Bianco, Armandodoriano; Frezza, Claudio; Serafini, Mauro; Giacomello, Ginevra; Giuliani, C.; Bramucci, Massimo; Quassinti, Luana; Lupidi, Giulio; Lucarini, Domenico; Papa, Fabrizio; Maggi, Filippo

doi:10.1002/cbdv.201600082

Cited by 27 publications

(20 citation statements)

References 38 publications

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“…perfoliata , S. euboea and S. cypria [7,39–42] . On the other hand, geniposidic acid ( 2 ) is reported for the first time in S. cypria and there are no data about its presence in other Sideritis species, whereas compounds 3 and 4 were both identified in Sideritis species [43,44] . The ent ‐kaurane diterpenoids 5 and 6 were both previously reported in wild S. cypria [5] .…”

Section: Resultsmentioning

confidence: 99%

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Lytra

Tomou

Chrysargyris

et al. 2021

Chemistry & Biodiversity

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Sideritis cypria Post is an endemic and endangered species of Northern Cyprus. The overall aim of the present study was to evaluate the total phenolic content, the antioxidant, the cytotoxic and the antimicrobial activity of the methanol extract obtained from the aerial parts of cultivated S. cypria. A bio‐guided approach led to the isolation of 27 chemical compounds by using various analytical techniques. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy. The crude extract exerted strong antioxidant activity (DPPH and FRAP assays) which was attributed to its high total phenolic content. Furthermore, groups rich in phenolic content showed highest antioxidant property, whereas groups with phytosterols, diterpenoids and apigenin derivatives exerted cytotoxic effects in MDA‐MB231 cancer cell line by the MTT method. Moreover, the cytotoxic activity of four isolated apigenin derivatives was evaluated in the same cancer cells. The antimicrobial activity of the extract and groups were measured, demonstrating lack of activity. To the best of our knowledge, this survey is the first report on the biological activities of the methanol extract of S. cypria.

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Section: Resultsmentioning

confidence: 99%

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Lytra

Tomou

Chrysargyris

et al. 2021

Chemistry & Biodiversity

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“…The EO was tested against HepG2 cell line, and cytotoxicity was determined using MTT assay. The IC 50 value obtained for the EO was 1.25 μL/mL [39].…”

Section: Origanummentioning

confidence: 87%

Cytotoxic Activity of Essential Oils of Some Species from Lamiaceae Family

Pérez-González¹,

Pérez‐Ramos²,

Méndez-Cuesta³

et al. 2019

Cytotoxicity - Definition, Identification, and Cytotoxic Compounds

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Cancer is considered one of the most lethal diseases in the world, with a prevalence of 439.2 cases and 163.5 deaths per 100,000 inhabitants, in the period from 2011 to 2015; this disease has a greater impact in underdeveloped countries. For the treatment of this disease, a combination of chemotherapy with surgery or radiation is generally used, however, it is not exempt from adverse effects or resistance of the tumor to this type of treatment, for this reason the search for new treatments is constant. The plants are a possible source to achieve this; Lamiaceae is a family of plants widely distributed on the planet and has been used traditionally for the treatment of different diseases, and various essential oils with the potential for cancer treatment have been isolated from this species. The scope of this review is to present 46 essential oils isolated from different species of Lamiaceae which have been tested against different cancer cell lines.

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“…(Tomou et al, 2019), S. montana L. (Koleva et al, 2003;Fraga, 2012), S. montana L. subsp. montana (Venditti et al, 2016), S. germanicopolitana Bornm (Kirmizibekmez et al, 2019), S. perfoliata L. subsp. perfoliata (Chrysargyris et al, 2019b), and S. syriaca L. (Koleva et al, 2003;Fraga, 2012).…”

Section: Discussionmentioning

confidence: 99%

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

et al. 2020

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Sideritis species are recognized as important medicinal plants and their commercial demand is continuously on the rise both in the European and in the global market. Consequently, the cultivation of Sideritis species has been occurred to successfully meet the need for mass production of high-quality plant material. The present study was undertaken in order to investigate the chemical composition of cultivated S. cypria. Infusions of flowers and leaves were prepared separately, according to the European Medicine Agency (EMA) monograph. The infusion of the flowers revealed the presence of four flavones, isoscutellarein-7-O-[6′″-O-acetyl-b-D-allopyranosyl-(1!2)-b-Dglucopyranoside, its 4′-O-methyl-derivative, 4′-O-methyl-hypolaetin-7-O-[6′″-O-acetylb-D-allopyranosyl-(1!2)-b-D-glucopyranoside, and isoscutellarein-7-O-[6′″-O-acetyl-b-D-allopyranosyl-(1!2)]-6″-O-acetyl-b-D-glucopyranoside; four phenylethanoid glucosides, acteoside, leucosceptoside A, lamalboside, and leonoside A; one iridoid, melittoside, and one phenolic acid, chlorogenic acid, while the infusion of the leaves of the same population afforded the same first two flavones; five phenylethanoid glucosides, acteoside, leucosceptoside A, lavandulifolioside, leonoside A, and lamalboside; melittoside and chlorogenic acid. The structural elucidation of the isolated compounds was undertaken by high-field NMR spectroscopy. Moreover, the essential oils of the flowers and leaves were studied by GC-MS, separately. In addition, the mineral, bioactive compounds, protein and carbohydrate contents were evaluated for both plant materials.

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Secondary Metabolites, Glandular Trichomes and Biological Activity of Sideritis montana L. subsp. montana from Central Italy

Cited by 27 publications

References 38 publications

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Bio‐Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays

Cytotoxic Activity of Essential Oils of Some Species from Lamiaceae Family

Traditionally Used Sideritis cypria Post.: Phytochemistry, Nutritional Content, Bioactive Compounds of Cultivated Populations

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