Secondary Metabolites from the Fresh Leaves of Pinus yunnanensis Franch

Abstract

Fifteen metabolites, including two flavonols (1 -2), three lignans (3 -5), and ten diterpenoids (6 -15), were isolated from the leaves of Pinus yunnanensis. Among them, flavanonol (1) were identified as undescribed flavonol derivative with natural rarely B-ring fission lactone. Massive spectroscopic methods, the DP4 + probabilities and CD/ECD calculations were applied to establish the structure of component 1. Among these compounds, taxifolin (2) showed potent cytotoxicity, having IC 50 values from 21.33 to 45.48 μg/mL, it also showed broad antibacterial activity against human pathogens with MIC values from 32 to 64 μg/mL.