Secondary metabolites from Antarctic marine-derived fungus <i>Penicillium crustosum</i> HDN153086

Liu, Congcong; Zhang, Zhenzhen; Feng, Yanyan; Gu, Qianqun; Li, Dehai; Zhu, Tianjiao

doi:10.1080/14786419.2018.1455045

Cited by 38 publications

(27 citation statements)

References 15 publications

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“…These derivatives were isolated from genera of Penicillium, Aspergillus, and Dichotomomyces collected from deep-sea sediments. Compounds 82-84 showed strong cytotoxicity with IC50 of 1.7 and 2 µ M against K562 and mouse lymphoma cell line, respectively; similarly, compounds 91-95 also showed strong cytotoxic activity [35][36][37]. Compounds 85-89 showed antibacterial activity against Staphylococcus aureus with the MIC values of 6.25-12.5 µ g/mL [21].…”

Section: Piperazine Derivativesmentioning

confidence: 96%

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

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Growing microbial resistance to existing drugs and the search for new natural products of pharmaceutical importance have forced researchers to investigate unexplored environments, such as extreme ecosystems. The deep-sea (>1000 m below water surface) has a variety of extreme environments, such as deep-sea sediments, hydrothermal vents, and deep-sea cold region, which are considered to be new arsenals of natural products. Organisms living in the extreme environments of the deep-sea encounter harsh conditions, such as high salinity, extreme pH, absence of sun light, low temperature and oxygen, high hydrostatic pressure, and low availability of growth nutrients. The production of secondary metabolites is one of the strategies these organisms use to survive in such harsh conditions. Fungi growing in such extreme environments produce unique secondary metabolites for defense and communication, some of which also have clinical significance. Despite being the producer of many important bioactive molecules, deep-sea fungi have not been explored thoroughly. Here, we made a brief review of the structure, biological activity, and distribution of secondary metabolites produced by deep-sea fungi in the last five years.

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Section: Piperazine Derivativesmentioning

confidence: 96%

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

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“…Citriperazines A and B (19,20) did not exhibit cytotoxic activity against three human prostate cancer cells (22Rv1, PC-3 and LNCaP) at concentrations up to 100 µM, also without any significant effect on cell cycle progression [22]. Cytotoxic effects have been also reported for saroclazine B (7) against HeLa (cervyx uteri carcinoma) cells (IC 50 4.2 µM) [24], and fusaperazine F (15) against the K562 (chronic myelogenous leukemia) cell line (IC 50 12.7 µM) [21].…”

Section: Biological Activitiesmentioning

confidence: 95%

Occurrence and Properties of Thiosilvatins

et al. 2019

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The spread of studies on biodiversity in different environmental contexts is particularly fruitful for natural product discovery, with the finding of novel secondary metabolites and structural models, which are sometimes specific to certain organisms. Within the large class of the epipolythiodioxopiperazines, which are typical of fungi, thiosilvatins represent a homogeneous family that, so far, has been reported in low frequency in both marine and terrestrial contexts. However, recent observations indicate that these compounds have been possibly neglected in the metabolomic characterization of fungi, particularly from marine sources. Aspects concerning occurrence, bioactivities, structural, and biosynthetic properties of thiosilvatins are reviewed in this paper.

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“…For example, a marine fungus of the Penicillium genus [37] has been the source for 2,5-diketopiperazine called penicillatide B (6), which belongs to the family of previously known peptides isolated from other marine sources [38,39]. Recently, a new member of the fusaperazine family, fusaperazine F (9), with moderate cytotoxicity, was isolated from an extremophilic micromycete [40]. Interestingly, its well-known ana-BARANOVA et al log, fusaperazin E [41], which differs in the geometry of the double bond, was not active.…”

Section: Peptides Diketopiperazines and Related Compoundsmentioning

confidence: 99%

Antibiotics from Extremophilic Micromycetes

et al. 2020

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Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists’ attention for several decades due to the biotechnological potential of enzymes inherent in extremophiles. These enzymes (also called extremozymes) are used in the production of food and detergents and other industries. At the same time, the inhabitants of extreme econiches remained almost unexplored for a long time in terms of the chemistry of natural compounds. In recent years, the emergence of new antibiotic-resistant strains of pathogens, which affect humans and animals has become a global problem. The problem is compounded by a strong slowdown in the development of new antibiotics. In search of new active substances and scaffolds for medical chemistry, researchers turn to unexplored natural sources. In recent years, there has been a sharp increase in the number of studies on secondary metabolites produced by extremophiles. From the discovery of penicillin to the present day, micromycetes, along with actinobacteria, are one of the most productive sources of antibiotic compounds for medicine and agriculture. Many authors consider extremophilic micromycetes as a promising source of small molecules with an unusual mechanism of action or significant structural novelty. This review summarizes the latest (for 2018–2019) experimental data on antibiotic compounds, which are produced by extremophilic micromycetes with various types of adaptation. Active metabolites are classified by the type of structure and biosynthetic origin. The data on the biological activity of the isolated metabolites are summarized.

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Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

Cited by 38 publications

References 15 publications

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Occurrence and Properties of Thiosilvatins

Antibiotics from Extremophilic Micromycetes

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