Secondary Metabolites Found among the Species Trattinnickia rhoifolia Willd

Souza, Agerdânio Andrade de; Ortíz, Brenda Lorena Sánchez; Koga, Rosemary de Carvalho Rocha; Sales, Priscila Faimann; Cunha, Divino Bruno da; Guerra, Ana Luiza Mantovaneli; Souza, Gisele Custódio de; Carvalho, José Carlos Tavares

doi:10.3390/molecules26247661

Cited by 2 publications

(1 citation statement)

References 13 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inclusion criteria for this study were original articles exclusive to the genus and species studied with full text available in portuguese, english or other languages. Exclusion criteria included abstracts, online sites without scientific sources, incomplete text, and unrelated or repeated articles, according to the methodology previously described [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model

et al. 2023

View full text Add to dashboard Cite

Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme in the process of pigmentation through melanin is tyrosinase, which catalyzes the first and only limiting step in melanogenesis. Since the discovery of its methanogenic properties, tyrosinase has been the focus of research related to the anti-melanogenesis. In addition to developing more effective and commercially safe inhibitors, more studies are required to better understand the mechanisms involved in the skin depigmentation process. However, in vivo assays are necessary to develop and validate new drugs or molecules for this purpose, and to accomplish this, zebrafish has been identified as a model organism for in vivo application. In addition, such model would allow tracking and studying the depigmenting activity of many bioactive compounds, important to genetics, medicinal chemistry and even the cosmetic industry. Studies have shown the similarity between human and zebrafish genomes, encouraging their use as a model to understand the mechanism of action of a tested compound. Interestingly, zebrafish skin shares many similarities with human skin, suggesting that this model organism is suitable for studying melanogenesis inhibitors. Accordingly, several bioactive compounds reported herein for this model are compared in terms of their molecular structure and possible mode of action in zebrafish embryos. In particular, this article described the main metabolites of Trichoderma fungi, in addition to substances from natural and synthetic sources.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model

et al. 2023

View full text Add to dashboard Cite

show abstract

Acute Toxicity and Anti-Inflammatory Activity of Trattinnickia rhoifolia Willd (Sucuruba) Using the Zebrafish Model

et al. 2022

View full text Add to dashboard Cite

The species Trattinnickia rhoifolia Willd, (T. rhoifolia), which belongs to the Burseraceae family, is widely used in ethnopharmacological cultural practices by traditional Amazonian people for anti-inflammatory purposes, sometimes as their only therapeutic resource. Although it is used in teas, infusions, macerations and in food, the species is still unexplored in regard to its pharmacophoric potential and chemical profile. Therefore, the aim of this study was to conduct a phytochemical characterization of the hydroethanolic extract of T. rhoifolia leaves (HELTr) and to evaluate the acute toxicity and anti-inflammatory activity of this species using zebrafish (Danio rerio). The extract was analyzed by gas chromatography–mass spectrometry (GC-MS). The evaluation of the acute toxicity of the HELTr in adult zebrafish was determined using the limit test (2000 mg/kg), with behavioral and histopathological evaluations, in addition to the analysis of the anti-inflammatory potential of HELTr in carrageenan-induced abdominal edema, followed by the use of the computational method of molecular docking. The phytochemical profile of the species is chemically diverse, suggesting the presence of the fatty acids, ester, alcohol and benzoic acid classes, including propanoic acid, ethyl ester and hexadecanoic acid. In the studies of zebrafish performed according to the index of histopathological changes (IHC), the HELTr did not demonstrate toxicity in the behavioral and histopathological assessments, since the vital organs remained unchanged. Carrageenan-induced abdominal edema was significantly reduced at all HELTr doses (100, 200 and 500 mg/kg) in relation to the negative control, dimethyl sulfoxide (DMSO), while the 200 mg/kg dose showed significant anti-inflammatory activity in relation to the positive control (indomethacin). With these activities being confirmed by molecular docking studies, they showed a good profile for the inhibition of the enzyme Cyclooxygenase-2 (COX-2), as the interactions established at the sites of the receptors used in the docking study were similar to the controls (RCX, IMN and CEL). Therefore, the HELTr has an acceptable degree of safety for acute toxicity, defined in the analysis of behavioral changes, mortality and histopathology, with a significant anti-inflammatory action in zebrafish at all doses, which demonstrates the high pharmacophoric potential of the species. These results may direct future applications and drug development but still require further elucidation.

show abstract

Secondary Metabolites Found among the Species Trattinnickia rhoifolia Willd

Cited by 2 publications

References 13 publications

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model

Acute Toxicity and Anti-Inflammatory Activity of Trattinnickia rhoifolia Willd (Sucuruba) Using the Zebrafish Model

Contact Info

Product

Resources

About