Secondary Metabolites and Antioxidant Activity of Limonium duriusculum (de Girard) Kuntze Extracts

Protective Effect of Phenolic Compounds Isolated from Mugwort (Artemisia argyi) against Contrast-Induced Apoptosis in Kidney Epithelium Cell Line LLC-PK1

“…KO1-107-6 (6.13 g) was subjected to Sephadex LH-20 CC and eluted with CHCl 3 –MeOH (1:1) to yield 7 fractions (designated as TH5-47-1 to -7). TH5-47-6 (125.9 mg) was separated by preparative HPLC (40–70% MeOH) to produce trans-ferulic acid ( 8 , 6.7 mg) [49], vanillic acid ( 13 , 14.8 mg) [50] and methyl caffeate ( 14 , 1.5 mg) [51]. Fraction KO1-107-7 (7.1 g) was subjected to Sephadex LH-20 CC and eluted with CHCl 3 –MeOH 2:1) to produce 5 fractions (designated as TH5-57-1 to -5).…”

“…Fraction TH5-57-4 (377.8 mg) was fractionated by silica gel CC and eluted with a gradient condition of n -hexane–EtOAc (1:0 to 1:1) to yield 7 fractions designated as TH5-61-1 to -7. TH5-61-1 (138.1 mg) was separated by preparative HPLC (35–80% MeOH) to produce 4-hydroxybenzoic acid ( 10 , 17.1 mg) [50], 3-(2-hydroxyphenyl)acrylic acid ( 11 , 70 mg) [52], and salicylic acid ( 12 , 10.9 mg) [53]. TH5-57-5 (50.9 mg) was separated by preparative HPLC (25–85% MeOH) to produce 1H-indole-3-carboxylic acid ( 9 , 4.1 mg) [54].…”

Limonium duriusculum (de Girard) Kuntze Exhibits Anti-inflammatory Effect Via NF-κB Pathway Modulation

“…Apigenin and apigenin7-O--(6''-methylglucuronide) were accumulated in this herb, to more than 1.6 g and 1.1 g per kg of air-dried plant material, respectively. Two newly identified flavones named duriusculin A and duriusculin B as well as six other flavones were also present [9].…”

“…and other names [3][4][5][6][7][8]] is a plant belonging to the Plumbaginaceae family and grows along the western area of the Mediterranean. Historically the aforementioned herb is known to be used in folk and modern medicine by local populations to treat allergies [9]. As reported previously, it contains numerous kinds of active chemical compounds.…”

“…In a previous study it was revealed that L. duriusculum exerts anti-oxidant activities [9]. Moreover, it was found recently that the n-butanolic extract of aerial parts of L. duriusculum had significant anti-proliferative, growth inhibitory and anti-tumor activities in HCT116 p53 wild type cells [10].…”