Secondary malignant neoplasms in patients with bladder carcinoma

Greven, Kathryn M.; Spera, John A.; Solin, Lawrence J.; Whittington, Richard; Wein, Alan J.; Hanks, Gerald E.

doi:10.1016/0090-4295(92)90289-9

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…It is interesting to note that we found that survivors of bladder cancer demonstrated the highest incidence of second primary malignancies, with 10‐year and 20‐year incidence rates of 19% and 34%, respectively, and that lung cancer represented the largest percentage of second primary malignancies among survivors of bladder cancer, at 25%. These findings are consistent with prior studies reporting an increased risk of lung cancer in the population of survivors of bladder cancer . Both bladder cancer and lung cancer harbor some of the highest rates of somatic mutations of any malignancy, and both are strongly linked to exposure to tobacco smoke.…”

Section: Discussionsupporting

confidence: 91%

“…The secondary outcome of interest was death from a primary or secondary malignancy. Patient demographics included age in years (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)36-50, 51-65, 66-80, and 80), marital status (single, married/domestic partner, divorced/widowed/separated, or unknown), race (white, black, unknown, and other [included American Indian, Alaska Native, and Asian/Pacific Islander]), sex (male or female), and year of diagnosis (1992-1996, 1997-2000, 2001-2004, and 2005-2008). SEER merged ZIP code-level data for educational level and annual household income from the 2008 US Census data.…”

Section: Primary Outcome and Covariates Of Interestmentioning

confidence: 99%

“…These findings are consistent with prior studies reporting an increased risk of lung cancer in the population of survivors of bladder cancer. [22][23][24][25] Both bladder cancer and lung cancer harbor some of the highest rates of somatic mutations of any malignancy, and both are strongly linked to exposure to tobacco smoke. The current study finding that survivors of NHL are at an increased risk of developing secondary lung cancers also is consistent with prior reports, 26,27 most likely related to the therapeutic alkylating agents and radiotherapy commonly used in the treatment of lymphoma.…”

Section: Second Primary Malignancies In the Us/donin Et Almentioning

confidence: 99%

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Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008

Donin

Filson

Drakaki

et al. 2016

Cancer

266

256

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BACKGROUND: In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. METHODS: The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, uterus, kidney, melanoma, and non-Hodgkin lymphoma) between 1992 and 2008 from Surveillance, Epidemiology, and End Results data. Factors associated with the incidence of second primary malignancies were explored using bivariable and multivariable models, and mortality attributable to first and second primary malignancies was examined. RESULTS: A cohort of 2,116,163 patients was identified, 170,865 of whom (8.1%) developed a second primary malignancy. Survivors of bladder cancer had the highest risk of developing a second cancer. In a multivariable model controlling for age, race, tumor grade, stage of disease, marital status, educational level, and income, a history of non-Hodgkin lymphoma (hazard ratios of 2.70 and 2.88, respectively, for men and women) and bladder cancer (hazard ratios of 1.88 and 1.66, respectively, for men and women) predicted the highest risk of developing a second cancer. For patients with 2 incident cancers, 13% died of their initial cancer, but greater than one-half (55%) died of their second primary malignancy. Lung cancer was the cause of death in 12% of patients with 2 incident cancers. CONCLUSIONS: Nearly 1 in 12 patients diagnosed with a common cancer developed a second malignancy, the most common of which was lung cancer. Greater than one-half of patients with 2 incident cancers died of their secondary malignancy. The findings from the current study may inform care strategies among cancer survivors.

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Section: Discussionsupporting

confidence: 91%

Section: Primary Outcome and Covariates Of Interestmentioning

confidence: 99%

Section: Second Primary Malignancies In the Us/donin Et Almentioning

confidence: 99%

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Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008

Donin

Filson

Drakaki

et al. 2016

Cancer

266

256

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Risks and Surveillance of Second Malignant Tumors in Prostate and Bladder Cancer Survivors

Konski

2008

Cured II ■ LENT Cancer Survivorship Research and Education

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Bladder cancer following prostate cancer—An analysis of risk factors

Wegner

Meier

Klän

et al. 1994

International Urology and Nephrology

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Between 1969 and 1988, 1421 men had been treated for primary adenocarcinoma of the prostate. In 14 cases subsequent primary bladder cancer was observed, as compared to 5.98 cases to be expected, thus constituting a relative risk of 2.34. Seven of these cases developed synchronously (within 6 months), with a range of up to 10 years. Aetiologically, cigarette smoking was detected as the single most important denominator, whereas family history was positive for malignancy in only two cases.

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Secondary malignant neoplasms in patients with bladder carcinoma

Cited by 4 publications

References 14 publications

Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008

Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008

Risks and Surveillance of Second Malignant Tumors in Prostate and Bladder Cancer Survivors

Bladder cancer following prostate cancer—An analysis of risk factors

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