Secondary Malignancies Across the Age Spectrum

Ng, Andrea K.; Kenney, Lisa B.; Gilbert, Ethel S.; Travis, Lois B.

doi:10.1016/j.semradonc.2009.09.002

Cited by 119 publications

(95 citation statements)

References 118 publications

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“…However, if unrepaired, DNA lesions may give rise to chromosome aberrations, which are able to interfere with the transcription and replication of DNA, resulting in cytotoxic and mutagenic effects. Due to all these characteristics, growing evidence suggests that secondary neoplasms may arise as a consequence of chemotherapy (37,(40)(41)(42)(43).…”

Section: Antineoplastic Drugs In Cancer Treatmentmentioning

confidence: 99%

Forgotten public health impacts of cancer – an overview

Viegas

Ladeira

Veiga

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs). There are also hidden costs such as health insurance premiums and nonmedical expenses that are worth noting. This paper intends to present an overview of the generally forgotten impacts that the increasing number of cancer cases can have on the environment, workers who handle antineoplastic drugs, and health services. The knowledge available of each of the impacts will be addressed and discussed regarding the expected development. Overall, lessons learnt reflect on the impact of cancer through aspects not commonly evidenced in the literature or even considered in socio-economic analysis, in part due to the fact that these are difficult to contemplate in direct and indirect cancer costs already defined. Attention may be drawn to the need of continuous investment in prevention to reduce the negative impact on the environment, and in the health of workers who handle antineoplastic drugs for patients' treatment. KEY WORDS: costs of cancer; global burden; occupational healthGlobally, cancer is a growing public health problem. It is the second cause of death (21 %) after cardiovascular diseases (48 %), followed by respiratory diseases (12 %) in the sector of non-communicable diseases or diseases caused by non-infectious and non-transmissible medical conditions (1). Important resources are mobilised in order to improve research on new therapeutics, and ultimately devise a cure for this particular disease. Despite the increase in the effectiveness and specificity of chemotherapeutic treatments, cancer still remains one of the most harmful diseases (2-4).In 2012, worldwide incidence of cancer rose to an estimated 14 million new cases per year, with an estimated 8.2 million cancer deaths. The most common cancers diagnosed were of lung (1.8 million cases, 13 %), breast (1.7 million, 11.9 %) and colon (1.4 million, 9.7 %) (1

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Section: Antineoplastic Drugs In Cancer Treatmentmentioning

confidence: 99%

Forgotten public health impacts of cancer – an overview

Viegas

Ladeira

Veiga

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…There are also some reports on the effects of radiotherapy for cancers and development of thyroid cancer. Thyroid cancer is one of the most common second cancers after radiotherapy during childhood for Hodgkin lymphoma, and significant increased risks of thyroid cancer have been observed from 5 to more than 40 years after childhood radiotherapy (Ng et al 2010). In addition to cancer treatment, radiotherapy for the treatment of benign conditions, including (but not restricted to) tinea capitis, hemangioma, and enlarged thymus, has been clearly associated with increased thyroid cancer risk (Ron 2003).…”

Section: Radiation and Thyroid Nodulesmentioning

confidence: 99%

Thyroid Disruptors: How They Act and How We React

Bufalo¹,

Silva²,

Barbieri³

et al. 2011

Basic and Clinical Endocrinology Up-to-Date

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“…A significant proportion of childhood cancer survivors (CCS) suffer adverse health outcomes including premature mortality, compared with general population [2]. One of the most serious adverse outcomes is subsequent primary neoplasms (SPNs), with the risk as high as six-fold over expected [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Screening for Subsequent Pancreatic Cancer in Childhood Cancer Survivors is Needed. A Case Report

Zadravec-Zaletel¹,

Cavlek²,

Gjidera³

2017

J Nucl Med Radiat Ther

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Introduction: The survival of children with cancer has improved considerably over the last decades which have led to a growing number of long term survivors. One of the most serious adverse outcomes in this population is subsequent primary neoplasms with the risk as high as six-fold over expected. The relative risk for subsequent pancreatic cancer in childhood cancer survivors is high, especially after subdiafragmatic radiotherapy and/or chemotherapy with alkylating agents. The survival of patient with advanced pancreatic cancer is very low, and early diagnosis is of vital importance.

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Secondary Malignancies Across the Age Spectrum

Cited by 119 publications

References 118 publications

Forgotten public health impacts of cancer – an overview

Forgotten public health impacts of cancer – an overview

Thyroid Disruptors: How They Act and How We React

Screening for Subsequent Pancreatic Cancer in Childhood Cancer Survivors is Needed. A Case Report

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