Secondary hypokalemic paralysis with bulbar weakness and reversible electrophysiologic abnormalities: A case report and systematic review

Ignacio, Katrina Hannah D.; Bagnas, Marjorie Anne C.; Espiritu, Adrian I.; Reyes, Jose Paciano

doi:10.1016/j.jocn.2019.08.063

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Moreover, tingling and paresthesia may occur in both hypokalaemia and GBS. Recent evidence suggests that hypokalaemia per se may be associated with electrophysiological findings similar to that of axonal pathologies, that is, reduction in CMAP amplitude and SNAP 17. During the attack of hypokalaemic paralysis, there may be evidence of decreased CMAP and electrical silence of the affected muscles in electrodiagnostic studies depending on the severity of involvement, attributable to muscle membrane hyperpolarisation secondary to hypokalaemia.…”

Section: Discussionmentioning

confidence: 99%

Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge

et al. 2022

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Acute-onset quadriparesis is not only debilitating and a grave concern for the patient but also perturbs the clinician as it demands early diagnosis and prompt management to prevent catastrophic outcome due to respiratory failure. Guillain-Barré syndrome (GBS) and hypokalaemia are notorious causes of acute-onset lower motor neuron (LMN) quadriparesis and warrant a rapid evaluation to necessitate early management. However, coexistence of these two entities is extremely rare and may pose a diagnostic and therapeutic challenge and mandates exclusion of either condition to avoid a poor outcome. We hereby report a case of a young woman who presented with an acute-onset LMN quadriparesis, initially found to have significant hypokalaemia with poor response to supplementation and was further evaluated to have an axonal variant of GBS.

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Section: Discussionmentioning

confidence: 99%

Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge

et al. 2022

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“… 2 The clinical phenotype has been described as episodic weakness of the limbs, and/or generalized weakness, typically lasting hours. While bulbar symptoms have been reviewed recently in secondary hypo kalemic PP, 3 in hyperkalemic disease brainstem musculature symptoms are undescribed in the medical literature, particularly as the prime manifestation of sporadic disease. We report here a case of adult‐onset, sporadic hyperkalemic periodic paralysis, with primary brainstem musculature involvement, thought to be recurrent transient ischemic attacks for decades.…”

Section: Introductionmentioning

confidence: 99%

Secondary hypokalemic paralysis with bulbar weakness and reversible electrophysiologic abnormalities: A case report and systematic review

Cited by 2 publications

References 13 publications

Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge

Hypokalaemia with Guillain-Barré syndrome: a diagnostic and therapeutic challenge

Sporadic adult‐onset brainstem hyperkalemic periodic paralysis masquerading as recurrent transient ischemic attacks

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