Secondary gliosarcoma after the treatment of primary glioblastoma multiforme

Andaloussi-Saghir, Khalid; Oukabli, Mohamed; Marjany, Mohammed El; Sifat, Hassan; Hadadi, Khalid; Mansouri, Hamid

doi:10.4297/najms.2011.3527.

Cited by 11 publications

(14 citation statements)

References 14 publications

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“…Previously reported clinical treatment-related experiences are limited. Currently, GS is treated using a protocol a GBM treatment protocol [8,16]. Moreover, studies on the response of GS to advanced therapies typically used for GBM, such as immunotherapy, cancer vaccine therapy, and gene therapy, are limited.…”

Section: Discussionmentioning

confidence: 99%

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Spinal metastasis of glioblastoma multiforme before gliosarcomatous transformation: a case report

et al. 2020

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Background: Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors. Intracranial GBM metastases to the spine are rarely detected clinically. Secondary gliosarcomas after treatment of primary GBM are rarely described. Case presentation: Herein, we report the case of a 53-year-old woman who presented to our emergency room with progressive headache and weakness on the left side. Plain computed tomography and contrast magnetic resonance imaging of the brain revealed an approximately 6.8 cm × 4.5 cm right temporoparietooccipital intraaxial cystic tumor with surrounding diffuse perifocal edema that caused midline shift toward the left. Emergency craniotomy was performed to remove the tumor, and pathological examination revealed GBM. The patient received proton beam therapy, Gliadel implantation, and oral temozolomide chemotherapy as well as targeted therapy with bevacizumab. Approximately 15 months after diagnosis, she underwent surgical resection of the right temporal recurrent tumor and was newly diagnosed as having a metastatic spinal tumor. Pathologically, the right temporal and metastatic spinal tumors were gliosarcoma and GBM, respectively. Conclusions: Concurrent spinal metastasis and gliosarcomatous transformation, which are two types of GBM complications, are rare. To our knowledge, this is the first report of a case of recurrent GBM with gliosarcoma after proton bean therapy.

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Section: Discussionmentioning

confidence: 99%

“…GS accounts for 1.8-8% of GBM cases and 0.48% of all intracranial tumor cases [6,7]. Most types of GS are de novo and are thus termed "primary GS," and those preceded by operative resection, radiotherapy, or chemotherapy are termed "secondary GS" [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Spinal metastasis of glioblastoma multiforme before gliosarcomatous transformation: a case report

et al. 2020

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“…1 It can be primary when it occurs "de novo" as opposed to secondary when initially the patient was treated as glioma and subsequently the recurrence reveals gliosarcoma. 2 In addition to histologically resembling GBM, it also shows mesenchymal component which resembles fibroblast, cartilage, bone, smooth muscle, striated muscle or adipose tissue. 3 Due to the sarcomatous component, they are prone for extracranial metastasis, most common sites being liver, lung and bone.…”

Section: Introductionmentioning

confidence: 99%

Long term palliation of a metastatic primary gliosarcoma with stereotactic body radiotherapy

Gururajachar

Polisetty

2016

Int J Cancer Ther Oncol

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Primary gliosarcoma (PGS) is rare and is known for extra cranial metastases. The overall outcome is dismal and hence the focus is on providing the best quality of life. This report describes a seventy-year-old lady who at presentation had metastatic primary gliosarcoma with intractable cough. Her lung lesion was treated with stereotactic body radiotherapy (SBRT) to a dose of 10 Gray per fraction for three consecutive days. She was free of cough till her death at eighteen months after treatment. This is probably the first reported case of excellent long-term quality of life in a patient of metastatic primary gliosarcoma.

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“…Distinction between secondary and radiation-induced GSs is subtle, since most patients with GBM receive radiotherapy as part of initial management, and hence can be considered radiation-induced. The length of time following radiotherapy to the development of GS in setting of prior GBM, however, is shorter (<12 months) than that observed in cases of nonglial radiation-induced GS (15+ months) [4][5][6][7]. The exact mechanism leading to the development of secondary/ radiation-induced GS, as for primary GS, is unknown.…”

mentioning

confidence: 98%

“…Survival of patients with secondary GS has been noted to exceed 1 year, which is twofold higher than radiation-induced GS patients in one review [4,5]; however, another report suggested that median survival of both groups is very poor, being only several months [6]. Since occurrence of all GSs, collectively, is rare, and cases of secondary and radiation-induced GSs are even more uncommon, with <60 instances having been documented in the literature [6,7], it is difficult to draw meaningful conclusions from these analyses. GS is a rare tumor comprising only 1-5% of all grade IV glioma cases [2].…”

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confidence: 99%

Therapeutic management of gliosarcoma in the temozolomide era

McAleer

Brown

2015

CNS Oncol.

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Gliosarcoma (GS) is a malignant, uncommon variant of high-grade glioma comprised of infiltrative glial and atypical sarcomatous cells, identified in adult and pediatric populations. GS has been subcategorized into primary (de novo) and secondary tumors, with the latter typically arising in the setting of prior glioblastoma. Due to its rarity, the pathogenesis, epidemiology and optimal therapy of GS have been based on small retrospective cohort studies, with treatment presently utilizing regimens established for other high-grade gliomas, including combination of resection, radiotherapy and temozolomide-based chemotherapy. As more information is gathered about GS molecular profiles, novel treatment strategies may be developed to improve outcomes of GS patients. Here we summarize results of GS management with focus on the temozolomide era.

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Secondary gliosarcoma after the treatment of primary glioblastoma multiforme

Cited by 11 publications

References 14 publications

Spinal metastasis of glioblastoma multiforme before gliosarcomatous transformation: a case report

Spinal metastasis of glioblastoma multiforme before gliosarcomatous transformation: a case report

Long term palliation of a metastatic primary gliosarcoma with stereotactic body radiotherapy

Therapeutic management of gliosarcoma in the temozolomide era

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